Study To Compare Avelumab In Combination With Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment In Patients... | NCT02952586 | Trialant

Study To Compare Avelumab In Combination With Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment In Patients... | NCT02952586 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: INCLUSION CRITERIA

Histological diagnosis of squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx

HPV negative disease, Stage III, IVa, IVb; non-oropharyngeal HPV positive disease Stage III, IVa, IVb, HPV positive oropharyngeal disease T4 or N2c or N3

No prior therapy for advanced stage SCCHN; eligible for definitive CRT with curative intent.

Available tumor samples for submission or willing to undergo further tumor biopsies:

Age ≥18 years (≥19 in Korea;20 years in Japan and Taiwan).

ECOG Performance Status 0 or 1

Adequate bone marrow function

Adequate renal function

Adequate liver function

Pregnancy test (for patients of childbearing potential) negative at screening

EXCLUSION CRITERIA

Prior immunotherapy with an anti PD 1, anti PD L1, anti PD L2, anti CD137, or anti CTLA 4 antibody (including ipilimumab), or any other antibody or drug specifically targeting T cell co stimulation or immune checkpoint pathways.

Major surgery 4 weeks prior to randomization.

Prior malignancy requiring tumor-directed therapy within the last 2 years prior to enrollment, or concurrent malignancy associated with clinical instability. Exceptions for disease within the 2 years are superficial esophageal cancer (TIS or T1a) fully resected by endoscopy, prostate cancer (Gleason score 6) either curatively treated or deemed to not require treatment, ductal IS carcinoma of the breast that has completed curative treatment, adequately treated basal cell or squamous cell skin cancer.

Active autoimmune disease

Any of the following in the 6 months prior to randomization: myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure, cerebrovascular accident, transient ischemic attack, or symptomatic pulmonary embolism.

Active infection requiring systemic therapy.

Use of immunosuppressive medication at time of randomization

Prior organ transplantation including allogenic stem-cell transplantation.

Diagnosis of prior immunodeficiency or known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) related illness.

Hepatitis B virus (HBV) or hepatitis C virus (HCV) infection

Vaccination within 4 weeks prior to randomization.

Current use of or anticipated need for treatment with other anti-cancer drugs.

Pregnant female patients, breastfeeding female patients, and male patients able to father children and female patients of childbearing potential who are unwilling or unable to use 2 highly effective methods of contraception as outlined in the protocol for the duration of the study and for at least 6 months after the last dose of cisplatin and 60 days after the last dose of avelumab/placebo (whichever is later).

Highlands Oncology Group

Fayetteville, Arkansas 72703, United States

Highlands Oncology Group

Rogers, Arkansas 72758, United States

Highlands Oncology Group

Springdale, Arkansas 72762, United States

The Oncology Institute of Hope and Innovation

Anaheim, California 92801, United States

CBCC Global Research, Inc. at Comprehensive Blood and Cancer Center

Bakersfield, California 93309, United States

Beverly Hills Cancer Center

Beverly Hills, California 90211, United States

Tower Hematology Oncology Medical Group

Beverly Hills, California 90211, United States

UCSD Radiation Oncology South Bay, Cancer Treatment Centers

Chula Vista, California 91914, United States

City of Hope Corona

Corona, California 92879, United States

Compassionate Care Research Group, Inc. at Compassionate Cancer Care Medical Group, Inc.

Corona, California 92879, United States

The Oncology Institute of Hope and Innovation

Downey, California 90241, United States

City of Hope (City of Hope National Medical Center, City of Hope Medical Center)

Duarte, California 91010, United States

The Oncology Institute of Hope and Innovation

Glendale, California 91204, United States

UC San Diego Medical Center- La Jolla (Thornton Hospital)

La Jolla, California 92037, United States

UC San Diego Moores Cancer Center

La Jolla, California 92093, United States

City of Hope Antelope Valley

Lancaster, California 93534, United States

The Oncology Institute of Hope and Innovation

Long Beach, California 90805, United States

The Oncology Institute of Hope and Innovation

Los Angeles, California 90033, United States

Cedars Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute

Los Angeles, California 90048, United States

The Oncology Institute of Hope and Innovation

Lynwood, California 90262, United States

The Oncology Institute of Hope and Innovation

Montebello, California 90640, United States

UC Irvine Medical Center

Orange, California 92868-3201, United States

Compassionate Care Research Group, Inc. at Compassionate Cancer Care Medical Group, Inc.

Riverside, California 92501, United States

UC San Diego Medical Center- Hillcrest

San Diego, California 92103, United States

The Oncology Institute of Hope and Innovation

Santa Ana, California 92705, United States

City of Hope South Pasadena

South Pasadena, California 91030, United States

The Oncology Institute of Hope and Innovation

Torrance, California 90503, United States

The Oncology Institute of Hope and Innovation

West Covina, California 91790, United States

The Oncology Institute of Hope and Innovation

Whittier, California 90602, United States

Rocky Mountain Lions Eye Institute

Aurora, Colorado 80045, United States

University of Colorado Denver CTO/CTRC

Aurora, Colorado 80045, United States

University of Colorado Hospital - Anschutz Inpatient Pavilion

Aurora, Colorado 80045, United States

University of Colorado Hospital - Anschutz Outpatient Pavilion

Aurora, Colorado 80045, United States

University Of Colorado Hospital Cancer Center

Aurora, Colorado 80045, United States

Cypress Hematology & Oncology

Denver, Colorado 80210, United States

Cypress Hematology and Oncology

Parker, Colorado 80138, United States

Sylvester at Coral Gables

Coral Gables, Florida 33146, United States

Sylvester at Deerfield Beach

Deerfield Beach, Florida 33442, United States

Specialist Global LLC

Hialeah, Florida 33012, United States

Memorial Cancer Institute at Memorial Regional Hospital

Hollywood, Florida 33021, United States

Hollis Cancer Center

Lakeland, Florida 33805, United States

Sylvester Comprehensive Cancer Center

Miami, Florida 33136, United States

Memorial Cancer Institute at Memorial Hospital West

Pembroke Pines, Florida 33028, United States

Sylvester at Plantation

Plantation, Florida 33324, United States

H. Lee Moffitt Cancer Center and Research Institute

Tampa, Florida 33612, United States

Primary Healthcare Associates

Flossmoor, Illinois 60422, United States

Ingalls Memorial Hospital

Harvey, Illinois 60426, United States

Primary Healthcare Associates

Harvey, Illinois 60426, United States

Primary Healthcare Associates

Tinley Park, Illinois 60477, United States

IU Health Arnett Cancer Center

Lafayette, Indiana 47904, United States

Kansas City VA Radiation Oncology Clinic

Overland Park, Kansas 66212, United States

Ashland-Bellefonte Cancer Center

Ashland, Kentucky 41101, United States

Norton Cancer Institute

Louisville, Kentucky 40202, United States

Norton Hospital

Louisville, Kentucky 40202, United States

University Medical Center, Inc.

Louisville, Kentucky 40202, United States

Norton Brownsboro Hospital

Louisville, Kentucky 40241, United States

Norton Cancer Institute

Louisville, Kentucky 40241, United States

Highlands Cancer Center

Prestonsburg, Kentucky 41653, United States

Maryland Proton Treatment Center

Baltimore, Maryland 21201, United States

University of Maryland School of Medicine

Baltimore, Maryland 21201, United States

University of Maryland, Greenebaum Comprehensive Cancer Center

Baltimore, Maryland 21201, United States

Dana-Farber Cancer Institute

Boston, Massachusetts 02215, United States

Karmanos Cancer Institute

Detroit, Michigan 48201, United States

Henry Ford Hospital

Detroit, Michigan 48202, United States

Karmanos Cancer Institute

Farmington Hills, Michigan 48334, United States

Herbert-Herman Cancer Center, Sparrow Hospital

Lansing, Michigan 48912, United States

Siteman Cancer Center- St. Peters

City of Saint Peters, Missouri 63376, United States

University of Missouri- Ellis Fischel Cancer Center

Columbia, Missouri 65212, United States

Siteman Cancer Center - West County

Creve Coeur, Missouri 63141, United States

Kansas City VA Medical Center

Kansas City, Missouri 64128, United States

Barnes-Jewish Hospital

St Louis, Missouri 63110, United States

Washington University School of Medicine Siteman Cancer Center

St Louis, Missouri 63110, United States

Siteman Cancer Center - South County

St Louis, Missouri 63129, United States

Department of Radiation Oncology Methodist Hospital

Omaha, Nebraska 68114, United States

Oncology Hematology West, PC dba Nebraska Cancer Specialists

Omaha, Nebraska 68114, United States

Memorial Sloan Kettering Cancer Center-Basking Ridge

Basking Ridge, New Jersey 07920, United States

Hackensack University Medical Center

Hackensack, New Jersey 07601, United States

John Theurer Cancer Center at Hackensack University Medical Center

Hackensack, New Jersey 07601, United States

Memorial Sloan Kettering Cancer Center- Monmouth

Middletown, New Jersey 07748, United States

Memorial Sloan Kettering Cancer Center- Bergen

Montvale, New Jersey 07645, United States

University of New Mexico Comprehensive Cancer Center

Albuquerque, New Mexico 87131, United States

Memorial Sloan Kettering Cancer Center Commack

Commack, New York 11725, United States

Memorial Sloan Kettering Cancer Center Westchester

Harrison, New York 10604, United States

Bellevue Hospital Center

New York, New York 10016, United States

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York 10016, United States

NYU Langone Medical Center

New York, New York 10016, United States

NYU Langone Radiology

New York, New York 10016, United States

NYU Langone Radiology - Ambulatory Care Center East 41st Street

New York, New York 10017, United States

Memorial Sloan Kettering Cancer Center

New York, New York 10022, United States

Memorial Sloan Kettering Cancer Center: Breast and Imaging Center

New York, New York 10065, United States

Memorial Sloan Kettering Cancer Center

New York, New York 10065, United States

Stony Brook University

Stony Brook, New York 11794-7007, United States

Stony Brook Cancer Center

Stony Brook, New York 11794, United States

Montefiore-Einstein Center for Cancer Care

The Bronx, New York 10461, United States

Montefiore Medical Center

The Bronx, New York 10467, United States

Memorial Sloan Kettering Cancer Center- Nassau

Uniondale, New York 11553, United States

Oncology Specialists of Charlotte, PA

Charlotte, North Carolina 28204, United States

DJL Clinical Research, PLLC

Charlotte, North Carolina 28210, United States

Wake Forest Baptist Health

Winston-Salem, North Carolina 27157, United States

University Hospitals Cleveland Medical Center

Cleveland, Ohio 44106, United States

OU Medical Center

Oklahoma City, Oklahoma 73104, United States

Stephenson Cancer Center

Oklahoma City, Oklahoma 73104, United States

University of Oklahoma Health Sciences Center- Stephenson Cancer Center

Oklahoma City, Oklahoma 73104, United States

Lehigh Valley Health Network Cancer Center Pharmacy

Allentown, Pennsylvania 18103, United States

Lehigh Valley Health Network-Cedar Crest

Allentown, Pennsylvania 18103, United States

Radiation Oncology Cancer Services

Allentown, Pennsylvania 18103, United States

Lehigh Valley Health Network-Muhlenberg

Bethlehem, Pennsylvania 18017, United States

Precision Cancer Research / Gettysburg Cancer Center

Gettysburg, Pennsylvania 17325, United States

PinnacleHealth Cancer Institute

Harrisburg, Pennsylvania 17109, United States

PinnacleHealth Cancer Institute

Jacksville, Pennsylvania 17050, United States

Fox Chase Cancer Center

Philadelphia, Pennsylvania 19111, United States

UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania 15232, United States

UPMC Shadyside Radiation Oncology

Pittsburgh, Pennsylvania 15232, United States

MUSC- Rutledge Tower

Charleston, South Carolina 29403, United States

Medical University of South Carolina- Hollings Cancer Center

Charleston, South Carolina 29425, United States

MUSC SCTR Research Nexus Clinical Science Building

Charleston, South Carolina 29425, United States

MUSC- Ashley River Tower

Charleston, South Carolina 29425, United States

MUSC- Radiation Oncology

Charleston, South Carolina 29425, United States

MUSC- University Hospital

Charleston, South Carolina 29425, United States

GHS Cancer Institute

Easley, South Carolina 29640, United States

GHS Cancer Institute

Greenville, South Carolina 29605, United States

GHS Cancer Institute

Greenville, South Carolina 29615, United States

GHS Cancer Institute

Greer, South Carolina 29650, United States

GHS Cancer Institute

Seneca, South Carolina 29672, United States

GHS Cancer Institute

Spartanburg, South Carolina 29307, United States

The West Clinic, PC dba West Cancer Center

Germantown, Tennessee 38138, United States

The West Clinic PC dba West Cancer Center

Memphis, Tennessee 38104, United States

Henry-Joyce Cancer Clinic

Nashville, Tennessee 37232, United States

Texas Oncology El Paso Cancer Treatment Center

El Paso, Texas 79902, United States

William Beaumont Army Medical Center

El Paso, Texas 79920-5001, United States

William Beaumont Army Medical Center

El Paso, Texas 79920, United States

University of Texas Medical Branch

Galveston, Texas 77555, United States

Memorial Hermann Hospital - TMC

Houston, Texas 77030, United States

UTHealth/Memorial Hermann Cancer Center

Houston, Texas 77030, United States

UTMB Cancer Center at Victory Lakes

League City, Texas 77573, United States

Utah Cancer Specialists

Murray, Utah 84157, United States

Utah Cancer Specialists

Salt Lake City, Utah 84106, United States

Virginia Mason Medical Center

Seattle, Washington 98101, United States

VA Puget Sound Health Care System

Seattle, Washington 98108, United States

Chris O'Brien Lifehouse Medical Imaging

Camperdown, New South Wales 2050, Australia

Chris O'Brien Lifehouse Radiation Oncology Department

Camperdown, New South Wales 2050, Australia

Chris O'Brien Lifehouse

Camperdown, New South Wales 2050, Australia

Northern Sydney Cancer Centre

St Leonards, New South Wales 2065, Australia

Illawarra Shoalhaven Local Health District

Wollongong, New South Wales 2500, Australia

Barwon Health, University Hospital Geelong

Geelong, Victoria 3220, Australia

Austin Health

Heidelberg, Victoria 3084, Australia

Ordensklinikum Linz GmbH

Linz, A-4010, Austria

University Hospital Brussels

Brussels, 1090, Belgium

Grand Hopital de Charleroi - Site Notre-Dame

Charleroi, 6000, Belgium

Centre Hospitalier de Jolimont

Haine-Saint-Paul, 7100, Belgium

Site Sainte Elisabeth / CHU UCL Namur

Namur, 5000, Belgium

GZA Hospitals Campus Sint Augustinus

Wilrijk, 2610, Belgium

CHU de Quebec - Universite Laval

Québec, Quebec G1R 2J6, Canada

Beijing Cancer Hospital

Beijing, Beijing Municipality 100142, China

Fujian Cancer Hospital

Fuzhou, Fujian 350014, China

SUN Yat-Sen University Cancer Center

Guangzhou, Guangdong 510060, China

Cancer Center of Guangzhou Medical University/Oncology Department

Guangzhou, Guangdong 510095, China

Affiliated Tumor Hospital of Guangxi Medical University

Nanning, Guangxi 530021, China

Hai Nan General Hospital

Haikou, Hainan 570311, China

Harbin Medical University Cancer Hospital

Harbin, Heilongjiang 150081, China

Henan Cancer Hospital

Zhengzhou, Henan 450008, China

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei 430022, China

Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology/Cancer Center

Wuhan, Hubei 430030, China

Xiangya Hospital Central South University/Oncology Department

Changsha, Hunan 410008, China

Liaoning Cancer Hospital & Institute

Shenyang, Liaoning 110042, China

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality 200032, China

Shanghai East Hospital/Oncology Department

Shanghai, Shanghai Municipality 200123, China

West China Hospital of Sichuan University

Chengdu, Sichuan 610041, China

Tianjin Cancer Hospital

Tianjin, Tianjin Municipality 300060, China

Institut de Cancerologie de l'Ouest (ICO) - Site Paul Papin

Angers, 49055, France

Institut Sainte Catherine

Avignon, 84918, France

Hopital Pellegrin - Service de radiologie et d'imagerie

Bordeaux, 33075, France

Hopital Saint-Andre

Bordeaux, 33075, France

Cabinet de radiologie Privé - Dr Joseph Mocaer

Brest, 29220, France

Clinique Pasteur - CFRO

Brest, 29229, France

Hopital Franco-Britannique, Institut d'Oncologie Hauts-de-Seine Nord

Levallois-Perret, 92309, France

Institut Regional du Cancer Montpellier - Val d'Aurelle

Montpellier, 34298, France

Hopital prive du Confluent S.A.S.

Nantes, 44277, France

Hopital prive du Confluent S.A.S

Nantes, 44277, France

Clinique Hartmann

Neuilly-sur-Seine, 92200, France

Hopital Americain de Paris

Neuilly-sur-Seine, 92200, France

Centre Antoine Lacassagne

Nice, 06189, France

Institut Curie

Paris, 75005, France

Centre Hospitalier Prive Saint Gregoire

Saint-Grégoire, 35760, France

Institut de Cancerologie de l'Ouest (ICO) - Site Rene Gauducheau

Saint-Herblain, 44805, France

Institut de cancerologie de la Loire Lucien Neuwirth

Saint-Priest-en-Jarez, 42271, France

Centre Paul Strauss - Radiologie et medecine nucleaire

Strasbourg, 67065, France

ICANS - Institut de cancerologie Strasbourg Europe

Strasbourg, 67200, France

Institut Gustave Roussy

Villejuif, 94800, France

Helios Klinikum Berlin-Buch, Institut fur Rontgendiagnostik

Berlin, BUCH 13125, Germany

Helios Klinikum Berlin-Buch, Klinik fur Nuklearmedizin

Berlin, BUCH 13125, Germany

Helios Klinikum Berlin-Buch, Klinik fur Strahlentherapie

Berlin, BUCH 13125, Germany

Helios Klinikum Berlin-Buch

Berlin, BUCH 13125, Germany

Universitatsklinikum Dusseldorf

Düsseldorf, 40225, Germany

Universitatsklinikum Jena

Jena, 07745, Germany

Universitatsklinikum Jena

Jena, 07747, Germany

Universitätsklinikum Regensburg

Regensburg, 93042, Germany

General Oncology Hospital of Kifissia "Agioi Anargiroi"

Athens, Attica 14564, Greece

Attikon University Hospital

Haidari, Attica 12462, Greece

Euromedica General Clinic

Thessaloniki, 54645, Greece

Orszagos Onkologiai Intezet, B Belgyogyaszati Osztaly

Budapest, 1122, Hungary

Orszagos Onkologiai Intezet, Sugarterapias Osztaly

Budapest, 1122, Hungary

Uzsoki Utcai Korhaz

Budapest, 1145, Hungary

Debreceni Egyetem Klinikai Kozpont

Debrecen, 4032, Hungary

Petz Aladar Megyei Oktato Koraz, Onkoradiologiai osztaly

Győr, 9024, Hungary

Pecsi Tudomanyegyetem, Klinikai Kozpont, Onkoterapias Intezet

Pécs, 7624, Hungary

Szegedi Tudomanyegyetem, Szent-Gyorgyi Albert Klinikai Kozpont

Szeged, 6720, Hungary

St Luke's Radiation Oncology Network, St Luke's Hospital

Dublin, 6, Ireland

St James's Hospital

Dublin, 8, Ireland

St. James's Hospital

Dublin, 8, Ireland

Blackrock Clinic

Dublin, A94 E4X7, Ireland

Rambam Health Care Campus

Haifa, 3109601, Israel

Hadassah University Hospital, Department of Oncology

Jerusalem, 91120, Israel

Rabin Medical Center

Petah Tikva, 4941492, Israel

The Chaim Sheba M.C.Tel-Hashomer

Ramat Gan, 52621, Israel

ASST degli Spedali Civili di Brescia

Brescia, BS 25123, Italy

Istituto Scientifico Romagnolo per lo studio e la cura dei Tumori (I.R.S.T)

Meldola, FC 47014, Italy

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)

Meldola, FC 47014, Italy

Ospedale M. Bufalini

Cesena, Forlì-cesena 47521, Italy

IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)

Meldola, Forlì-cesena 47014, Italy

Presidio Ospedaliero Vito Fazzi

Lecce, LE 73100, Italy

AOU Policlinico Di Modena

Modena, MO 41124, Italy

Azienda Ospedaliero-Universitaria di Parma

Parma, PR 43126, Italy

UOC Oncologia Medica, AUSL della Romagna -RAVENNA

Lugo, RA 48022, Italy

IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)

Ravenna, RA 48121, Italy

UOC Oncologia Medica, AUSL della Romagna - RAVENNA

Ravenna, RA 48121, Italy

AULSS 9 - Scaligera Ospedale Mater Salutis

Legnago, VR 37045, Italy

Istituto Nazionale Tumori IRCCS - Fondazione Pascale

Naples, 80131, Italy

AUSL - IRCCS and Reggio Emilia

Reggio Emilia, 42123, Italy

Aichi cancer center central hospital

Nagoya, Aichi-ken 464-8681, Japan

Nagoya University Hospital

Nagoya, Aichi-ken 466-8560, Japan

National Cancer Center Hospital East

Kashiwa, Chiba 277-8577, Japan

National Hospital Organization Shikoku Cancer Center

Matsuyama, Ehime 791-0280, Japan

Hokkaido University Hospital

Sapporo, Hokkaido 060-8648, Japan

Kobe University Hospital

Kobe, Hyōgo 650-0017, Japan

Miyagi Cancer Center

Natori-shi, Miyagi 981-1293, Japan

Tohoku University Hospital

Sendai, Miyagi 980-8574, Japan

Osaka International Cancer Institute

Osaka, Osaka 541-8567, Japan

Kindai University Hospital

Sayama, Osaka 589-8511, Japan

Saitama Cancer Center

Kita-adachi-gun, Saitama 362-0806, Japan

Shizuoka Cancer Center

Sunto-gun, Shizuoka 411-8777, Japan

Jichi Medical University Hospital

Shimotsuke, Tochigi 329-0498, Japan

National Cancer Center Hospital

Chuo-ku, Tokyo 1040045, Japan

Cancer Institute Hospital, Japanese Foundation for Cancer Research

Koto-ku, Tokyo 135-8550, Japan

Centrum Onkologii im. prof. F. Lukaszczyka

Bydgoszcz, 85-796, Poland

Uniwersyteckie Centrum Kliniczne

Gdansk, 80-214, Poland

Centrum Onkologii - Instytut im. M. Sklodowskiej - Curie, Klinika Radioterapii i Chemioterapii

Gliwice, 44-101, Poland

SPZOZ Ministerstwa Spraw Wewnetrznych i Administracji z Warminsko-Mazurskim Centrum Onkologii

Olsztyn, 10-228, Poland

NZOZ Provita Prolife Centrum Medyczne

Tomaszów Mazowiecki, 97-200, Poland

Specjalistyczny Szpital Onkologiczny NU-MED sp. z o.o.

Tomaszów Mazowiecki, 97-200, Poland

Hospital Pedro Hispano

Matosinhos Municipality, Porto District 4464-513, Portugal

CUF Porto

Senhora da Hora, Porto District 4460-188, Portugal

Centro Hospitalar de Vila Nova de Gaia/Espinho, EPE

Vila Nova de Gaia, Porto District 4434-502, Portugal

Instituto Portugues de Oncologia de Coimbra Francisco Gentil, E.P.E.

Coimbra, 3000-075, Portugal

Centro Hospitalar do Porto, E.P.E.- Hospital de Santo Antonio

Porto, 4099-001, Portugal

Instituto Portugues de Oncologia do Porto Francisco Gentil, E.P.E.

Porto, 4200-072, Portugal

Centro Hospitalar São João, E.P.E

Porto, 4200-319, Portugal

Julio Teixeira

Porto, 4460-188, Portugal

SBIH "Chelyabinsk Regional Clinical Centre of Oncology and Nuclear Medicine"

Chelyabinsk, 454087, Russia

N. N. Blokhin NMRCO

Moscow, 115478, Russia

Budgetary Institution of Healthcare of Omsk Region "Clinical Oncology Dispensary"

Omsk, 644013, Russia

FSBI "National Medical Research Center of Oncology n.a. N.N. Petrov"

Saint Petersburg, 197758, Russia

SBIH "SPb Clinical Research Centre of Specialized Kinds of Medical Care (Oncology)"

Saint Petersburg, 197758, Russia

SBHI YaR "Regional Clinical Oncology Hospital"

Yaroslavl, 150054, Russia

Center for Proton Therapy, National Cancer Center

Goyang-si, Gyeonggi-do 10408, South Korea

Center for Specific Organ Cancer, National Cancer Center

Goyang-si, Gyeonggi-do 10408, South Korea

Department of Radiation Oncology, CHA Bundang Medical Center, CHA University

Seongnam-si, Gyeonggi-do 13496, South Korea

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do 13620, South Korea

Chonnam National University Hwasun Hospital

Hwasun-gun, Jeollanam-do 58128, South Korea

Division of Radiation Oncology, Seoul National University Hospital

Seoul, 03080, South Korea

Asan Medical Center

Seoul, 05505, South Korea

Division of Radiation Oncology, Asan Medical Center

Seoul, 05505, South Korea

Samsung Medical Center

Seoul, 06351, South Korea

SMG-SNU Boramae Medical Center

Seoul, 07061, South Korea

Department of Radiation Oncology, Ulsan University Hospital

Ulsan, 44033, South Korea

Ulsan University Hospital

Ulsan, 44033, South Korea

Institut Catala d'Oncologia Badalona, Hospital Germans Trias i Pujol

Badalona, Barcelona 08916, Spain

Hospital Universitario Donostia

Donostia / San Sebastian, Guipuzcoa 20014, Spain

Hospital Costa del Sol

Marbella, Malaga 29603, Spain

Hospital Clinico Universitario Virgen de la Arrixaca

El Palmar, Murcia 30120, Spain

Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain

Hospital Clinic de Barcelona

Barcelona, 08036, Spain

Hospital de la Santa Creu i Sant Pau

Barcelona, 08041, Spain

Hospital Universitario Reina Sofia

Córdoba, 14004, Spain

Institut Catala D'Oncologia de Girona

Girona, 17007, Spain

Complejo Hospitalario de Jaen

Jaén, 23007, Spain

Hospital Clinico San Carlos

Madrid, 28040, Spain

Hospital Universitario La Paz

Madrid, 28046, Spain

Hospital Virgen de la Victoria

Málaga, 29010, Spain

Hospital Universitario de Salamanca

Salamanca, 37007, Spain

Fundacion Instituto Valenciano de Oncologia

Valencia, 46009, Spain

Hospital Clinico Universitario Lozano Blesa

Zaragoza, 50009, Spain

Klinik fur Radiologie und Nuklearmedizin

Basel, Canton of Basel-City 4031, Switzerland

Klinik fur Strahlentherapie und Radioonkologie

Basel, Canton of Basel-City 4031, Switzerland

Universitatsspital Basel

Basel, Canton of Basel-City 4031, Switzerland

Centre Hospitalier Universitaire Vaudois

Lausanne, Canton of Vaud 1011, Switzerland

Kantonsspital Winterthur, Medizinische Onkologie

Winterthur, Canton of Zurich 8401, Switzerland

Kantonsspital Winterthur, Radiologie

Winterthur, Canton of Zurich 8401, Switzerland

Kantonsspital Winterthur

Winterthur, Canton of Zurich 8401, Switzerland

Istituto Oncologico della Svizzera Italiana IOSI, Ospedale San Giovanni

Bellinzona, Canton Ticino 6500, Switzerland

Radiologia ORBV, Ospedale San Giovanni

Bellinzona, Canton Ticino 6500, Switzerland

Institut fur Klinische Pathologie

Zurich, 8091, Switzerland

Klinik fur Nuklearmedizin

Zurich, 8091, Switzerland

Universitatsspital Zurich

Zurich, 8091, Switzerland

China Medical University Hospital

Taichung, 40447, Taiwan

Taichung Veterans General Hospital

Taichung, 40705, Taiwan

National Cheng Kung University Hospital

Tainan, 704, Taiwan

National Taiwan University Hospital

Taipei, 100, Taiwan

Taipei Veterans General Hospital

Taipei, 11217, Taiwan

Koo Foundation Sun Yat-Sen Cancer Center

Taipei, 112, Taiwan

Chang Gung Memorial Hospital-Linkou Branch

Taoyuan City, 333, Taiwan

NHS Grampian

Aberdeen, AB25 2ZN, United Kingdom

The Clatterbridge Cancer Centre NHS Foundation Trust

Bebington, CH63 4JY, United Kingdom

University Hospital Bristol NHS Foundation Trust

Bristol, BS2 8ED, United Kingdom

NHS Lothian, Western General Hospital

Edinburgh, EH4 2XU, United Kingdom

Guy's and St. Thomas' NHS Foundation Trust

London, SE1 9RT, United Kingdom