Kinetics and Ecology of Human Papillomavirus Genital Infections in Young Women

KINETICS AND ECOLOGY OF HUMAN PAPILLOMAVIRUS (HPV) GENITAL INFECTIONS IN YOUNG WOMEN

Most genital infections by human papillomaviruses (HPV) are asymptomatic or benign and clear within a few months or years. There infections are much less studies than chronic infections, even though they represent the main reservoir for the virus. The goal of this project is to decipher the kinetics of the virus and of the host immune response in acute HPV genital infections in your women. This will be performed by following women longitudinally and regularly in order to measure variations in virus load, immune cell count, cytokine concentration and antibody titers. The investigators will also investigate the interaction between these kinetics and host genetics and host vaginal microbiota

Inclusion Criteria:

• Sexually active with at least one new partner over the last 12 months
• Subjects must be able and willing to give written informed consent
• Living in the 'agglomération de Montpellier'

Exclusion Criteria:

• History of cervical pathology
• Pregnant or intending to become pregnant soon (in the coming year)
• Infected by HIV
• Undergoing (or planning to undergo) heavy treatment (biotherapy, chemotherapy, immunosuppression)
• Participation in a clinical trial involving administration of drugswithin the last 4 weeks before the screening date