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| Name | Class |
|---|---|
| German Federal Ministry of Economics and Technology | OTHER_GOV |
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The oral absorption and urinary excretion kinetics of the bioactive ingredients from rice bran (gamma-oryzanol, tocotrienols, tocopherols and ferulic acid esters) after incorporation into an oat porridge (oat porridge) compared to unprocessed rice bran extract oil were investigated. The influence of the type of preparation (with water vs. milk) of porridge on the bioavailability of the bioactive compounds was compared. The study followed a single dose (2 g rice bran extract), randomized, three armed crossover study design with ≥1-week washout periods. Plasma and urine samples were collected at intervals up to 24 h after intake.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rice bran extract | Experimental | 2 g of unprocessed rice bran extract |
|
| Porridge in water | Experimental | 35 g of porridge containing 2 g of rice bran extract mixed with 95 ml of warm water |
|
| Porridge in milk | Experimental | 35 g of porridge containing 2 g of rice bran extract mixed with 95 ml of warm milk (3.8% fat) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rice bran extract | Dietary Supplement |
| ||
| Porridge in water |
| Measure | Description | Time Frame |
|---|---|---|
| Mean area under the curve (AUC) of plasma concentration vs. time of total alfa, beta, gamma and delta tocopherols and tocotrienols [nmol/L*h] | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose | |
| Mean area under the curve (AUC) of plasma concentration vs. time of total ferulic acid [nmol/L*h] | Total ferulic acid after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose |
| Mean area under the curve (AUC) of plasma concentration vs. time of total gamma-oryzanol [nmol/L*h] | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose | |
| Mean maximum plasma concentration (Cmax) of total total alfa, beta, gamma and delta tocopherols and tocotrienols [nmol/L] | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose | |
| Mean maximum plasma concentration (Cmax) of total ferulic acid [nmol/L] | Total ferulic acid after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose |
| Mean maximum plasma concentration (Cmax) of total gamma-oryzanol [nmol/L] | Total gamma-oryzanol after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose |
| Time to reach maximum plasma concentration (Tmax) of total alfa, beta, gamma and delta tocopherols and tocotrienols [h] | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose | |
| Time to reach maximum plasma concentration (Tmax) of total ferulic acid [h] |
| Measure | Description | Time Frame |
|---|---|---|
| Serum aspartate transaminase activity [U/L] | 0, 4, 24h post-dose | |
| Serum alanine transaminase activity [U/L] | 0, 4, 24h post-dose | |
| Serum gamma-glutamyl transferase activity [U/L] |
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Inclusion Criteria:
Healthy Volunteers with blood chemistry values within normal ranges
Age 18 to 35 years
BMI 19 to 25 kg per m2
Exclusion Criteria:
Pregnancy or lactation
Alcohol and or drug abuse
Use of dietary supplements or any medications except contraceptives
Any known malignant, metabolic and endocrine diseases
Previous cardiac infarction
Dementia
Participation in a clinical trial within the past 1 week prior to recruitment
Smoking
Physical activity of more than 5 h per wk
Lactose intolerance
Milk intolerance
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| Name | Affiliation | Role |
|---|---|---|
| Jan Frank, Prof. Dr | University of Hohenheim | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Hohenheim | Stuttgart | Baden-Wurttemberg | 70599 | Germany |
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| Label | URL |
|---|---|
| Website of the research group | View source |
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| ID | Term |
|---|---|
| D000073879 | Rice Bran Oil |
| D014867 | Water |
| D008892 | Milk |
| ID | Term |
|---|---|
| D004042 | Dietary Fats, Unsaturated |
| D004041 | Dietary Fats |
| D005223 | Fats |
| D008055 | Lipids |
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|
| Porridge in milk | Dietary Supplement |
|
Total ferulic acid after deconjugation with beta-glucuronidase/sulphatase |
| 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose |
| Time to reach maximum plasma concentration (Tmax) of total gamma-oryzanol [h] | Total gamma-oryzanol after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose |
| Cumulative urinary excretion of total Vitamin E metabolites [nmol/g creatinine] | 0-24 h post dose |
| Cumulative urinary excretion of total ferulic acid [nmol/g creatinine] | 0-24 h post dose |
| Cumulative urinary excretion of total gamma-oryzanol [nmol/g creatinine] | 0-24 h post dose |
| 0, 4, 24h post-dose |
| Serum alkaline phosphatase activity [U/L] | 0, 4, 24h post-dose |
| Serum bilirubin | 0, 4, 24h post-dose |
| Serum uric acid [mg/dL] | 0, 4, 24h post-dose |
| Serum creatinine [mg/dL] | 0, 4, 24h post-dose |
| Serum total cholesterol [mg/dL] | 0, 4, 24h post-dose |
| Serum HDL cholesterol [mg/dL] | 0, 4, 24h post-dose |
| Serum LDL cholesterol [mg/dL] | 0, 4, 24h post-dose |
| Serum triacylglycerols [mg/dL] | 0, 4, 24h post-dose |
| LDL/HDL cholesterol ratio | 0, 4, 24h post-dose |
| Glomerular filtration rate [mL/min] | 0, 4, 24h post-dose |
| Serum glucose [mg/dL] | 0, 24h post-dose |
| D005224 |
| Fats, Unsaturated |
| D010938 | Plant Oils |
| D009821 | Oils |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
| D006878 | Hydroxides |
| D000468 | Alkalies |
| D007287 | Inorganic Chemicals |
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D003611 | Dairy Products |
| D005502 | Food |
| D019602 | Food and Beverages |