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The investigators sought to retrospectively assess whether the use of a intrauterine device to manipulate the uterus does affect the long-term oncologic outcomes of patients operated by laparoscopy for endometrial cancer
The investigators retrospectively collected data regarding patients who received operation by laparoscopy for presumed clinical stage I endometrial cancer. The subjects were then stratified according to the use or not of the uterine manipulator. The investigators also considered the actual type of manipulator used. Then disease-free, disease-specific and overall survival were evaluated, as well as all the possible factors associated with prognosis.
Data were retrieved from specifically designed research quality internal surgical databases, prospectively updated by trained residents on a regular basis, in order to capture all the possible surgical and follow-up data.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MANIPULATOR | Patients who were operated for endometrial cancer by laparoscopy with the use of a uterine manipulator |
| |
| NO MANIPULATOR | Patients who were operated for endometrial cancer by laparoscopy without the use of a uterine manipulator |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| UTERINE MANIPULATOR | Device | Patients were operated laparoscopically with the aid or not of an intrauterine probe to manipulate the uterus |
|
| Measure | Description | Time Frame |
|---|---|---|
| Disease recurrence | Relapse of disease during follow-up | 4 years |
| Measure | Description | Time Frame |
|---|---|---|
| disease specific survival | Kaplan Meyer curves and Log-rank test to explore disease-specific survival | 4 years |
| overall survival | Kaplan Meyer curves and Log-rank test to explore overall survival |
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Inclusion Criteria:
Exclusion Criteria:
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Women affected by early endometrial cancer
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| Name | Affiliation | Role |
|---|---|---|
| Stefano Uccella | Università degli Studi dell'Insubria | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27518143 | Background | Marcos-Sanmartin J, Lopez Fernandez JA, Sanchez-Paya J, Pinero-Sanchez OC, Roman-Sanchez MJ, Quijada-Cazorla MA, Candela-Hidalgo MA, Martinez-Escoriza JC. Does the Type of Surgical Approach and the Use of Uterine Manipulators Influence the Disease-Free Survival and Recurrence Rates in Early-Stage Endometrial Cancer? Int J Gynecol Cancer. 2016 Nov;26(9):1722-1726. doi: 10.1097/IGC.0000000000000808. | |
| 27312035 |
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| ID | Term |
|---|---|
| D016889 | Endometrial Neoplasms |
| ID | Term |
|---|---|
| D014594 | Uterine Neoplasms |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
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| 4 years |
| Background |
| Tinelli R, Cicinelli E, Tinelli A, Bettocchi S, Angioni S, Litta P. Laparoscopic treatment of early-stage endometrial cancer with and without uterine manipulator: Our experience and review of literature. Surg Oncol. 2016 Jun;25(2):98-103. doi: 10.1016/j.suronc.2016.03.005. Epub 2016 Mar 23. |
| D009369 |
| Neoplasms |
| D014591 | Uterine Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |