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The aim of this clinical trial is to investigate and compare the effect of piezoelectric surgery on tissue, cellular and molecular level of oral surgical wound healing and postoperative outcomes (pain, swelling, trismus) after lower third molar surgery in healthy patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| healthy, conventional surgery | Active Comparator | Surgical bone removal by conventional rotary burs in healthy patients during third molar surgery |
|
| healthy, piezo surgery | Experimental | Surgical bone removal by piezoelectric vibrations in healthy patients during third molar surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| piezo surgery | Procedure |
| ||
| conventional surgery |
| Measure | Description | Time Frame |
|---|---|---|
| SOD activity in alveolar bone specimen | Activity of enzyme superoxide dismutase in bone specimens obtained during lower third molar surgery | immediately after surgery |
| VEGF levels in alveolar bone specimen | immediately after surgery | |
| MMP-9 level in alveolar bone specimen | immediately after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bozidar M Brkovic, DDS,PhD | School of Dental Medicine, University of Belgrade | Principal Investigator |
| Milan V Vucetic, PhD student | School of Dental Medicine, University of Belgrade | Principal Investigator |
| Marija S Milic, DDS, PhD | School of Dental Medicine, University of Belgrade | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| School of Dental Medicine, University of Belgrade | Belgrade | 11000 | Serbia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32712962 | Derived | Bailey E, Kashbour W, Shah N, Worthington HV, Renton TF, Coulthard P. Surgical techniques for the removal of mandibular wisdom teeth. Cochrane Database Syst Rev. 2020 Jul 26;7(7):CD004345. doi: 10.1002/14651858.CD004345.pub3. |
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| ID | Term |
|---|---|
| D014095 | Tooth, Impacted |
| ID | Term |
|---|---|
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D059745 | Piezosurgery |
| ID | Term |
|---|---|
| D059708 | Ultrasonic Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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