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Enrollment was stopped early due to heavy workload at burn care centers and the impact of the COVID-19 pandemic.
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The prognostic of burn patients has improved over the last decades. Early excision of full thickness burns is thought to be one of the key factors which have led to prognostic improvement. Best timing for burn excision remain uncertain, however. In this multicenter observational study, we aim at exploring the impact of timing of surgery on outcome in severely ill burn patients using a propensity analysis.
The first aim of the study is to explore the impact of timing of the first surgery on outcome of severely ill burn patients. Because a randomization would not be feasible in this setting, we will use a propensity analysis in matching patients receiving early surgery and those receiving late surgery. Secondary aims are to evaluate the impact of the timing of surgery on morbidity (organs failure, infections, sepsis) but also to assess the diagnostic and prognostic value of plasma and urine biomarkers in severely ill burn patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Early surgery | Early Excision of full thickness burn First excision surgery of full -thickness burn performed within 48 hours from burn injury |
| |
| Late surgery | Late Excision of full thickness burn First excision surgery of full -thickness burn performed after 48 hours from burn injury |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Early Excision of full thickness burn | Procedure | first excision surgery of full -thickness burn performed within 48 hours from burn injury |
|
| Measure | Description | Time Frame |
|---|---|---|
| mortality | 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| Organ failure | 28 and 60 days | |
| Recovery from acute kidney | Until 28 and 60 days from burn injury | |
| Median Sequential Organ Failure Assessment score (SOFA score) during first 28 days |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with extensive skin burns, defined as greater than 20% of the total body surface
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| Name | Affiliation | Role |
|---|---|---|
| Matthieu Dr Legrand, MD, PhD | Saint-Louis Hospital, Paris, France | Principal Investigator |
| Mourad BENYAMINA, MD, PH | Saint-Louis Hospital, Paris, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Departement of Anesthesiology, Critical Care and Burn Unit; Saint-Louis hospital, University Paris Diderot | Paris | 75010 | France |
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| ID | Term |
|---|---|
| D002056 | Burns |
| D016638 | Critical Illness |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Serum and urine bank 1 / day of inclusion (D0): 1 sample (3 x 5 ml of blood). 1 sample (10 ml sample of urine) 2 / The seventh day of inclusion (D7): 1 sample (3 x 5 ml of blood) 1 sample (10 ml sample of urine) 3 / The twenty eighth day of inclusion (D28): 1 sample (3 x 5 ml of blood) 1 sample (10 ml sample of urine) 4 / The sixtieth day of inclusion (J60) or the day of the release from hospital: 1 sample (3 x 5 ml of blood) 1 sample (10 ml sample of urine) The aliquots will be stored locally at -20 °C or 80°C Every 6 months, they will be transported to the "Centre de Ressources Biologiques" (CRB) of the Lariboisière Hospital. The samples will be preserved for 10 years
| Late Excision of full thickness burn | Procedure | first excision surgery of full -thickness burn performed after 48 hours from burn injury |
|
|
Median Sequential Organ Failure Assessment score (SOFA score) during first 28 |
| First 28 days |
| Nosocomial infections (numbers) during first 60 days | Nosocomial infections (numbers) during first 60 days | First 60 days |
| Nosocomial sepsis during first 60 days | Nosocomial sepsis during first 60 days | First 60 days |
| Length of stay in the ICU | Length of stay in the ICU | One year |
| analog scale of quality of life | Functional sequel at one year, the patient will assesassess his overall quality of life since his accident Scale 1 to 10, with 1: poor, 10: good | One year |
| One year mortality | One year mortality | One year |