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| ID | Type | Description | Link |
|---|---|---|---|
| SDUSF-2015-20 - (115) | Other Identifier | PhD School - Faculty of Health Sciences, SDU |
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| Name | Class |
|---|---|
| Odense University Hospital | OTHER |
| Kolding Sygehus | OTHER |
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Anterior cruciate ligament reconstruction (ACLR) is high volume surgery, carried out in about 2800 patients annually in Denmark per year. ACLR patients (using hamstring auto-graft) have persistent hamstring strength deficiency when evaluated more than 1-2 years after ACL-reconstruction. The investigators have designed this randomized controlled trial (RCT) with the main purpose to investigate the effect of a targeted muscle strength exercise intervention on the neuromuscular rehabilitation of ACLR-patients compared with 'care-as- usual'.
The study is designed as a prospective, superiority, parallel-group with balanced randomization (1:1) RCT (Level of evidence: II) with blinded allocation, and outcome assessment according to the CONSORT statement (Consolidated Standards of Reporting Trials). 50 patients with ACL reconstruction and persistent hamstring muscle deficiency, will be recruited at the outpatient clinic 1-year follow-up, and allocated to one of two 12 weeks' interventions, either a) the supervised progressive strength and neuromuscular exercise group (SNG) with supervised training twice weekly. Or b) the control group (CON) receiving patient education based on a home-based exercise regime of low intensity, defined as 'care as usual'. Outcome measures include, maximal isometric knee flexor muscle strength (primary outcome), knee extensor strength, and the Knee injury and Osteoarthritis Outcome Score (KOOS) (secondary outcomes). In addition, the following explorative outcomes will be investigated; hamstring to quadriceps strength ratios, the International Knee Documentation Committee Subjective Knee Form (IKDC), magnetic resonance imaging (MRI) to evaluate tendon regeneration of the hamstrings and finally kinetic/kinematic biomechanical outcomes of knee related functional tasks.
To the investigators knowledge, this is the first RCT to investigate the efficacy of combined progressive resistance training and neuromuscular exercise in the late rehabilitation phase in patients demonstrating persistent limb-to-limb knee muscle asymmetry following ACLR. Reduced hamstring strength represents a potential risk factor for secondary ligament rupture and accelerated progression of osteoarthritis (OA). If deemed effective, the intervention paradigm introduced in this study may help to improve current treatment strategies.
Detailed study description available in the published study protocol:
"The effect of targeted exercise on kneemuscle function in patients with persistent hamstring deficiency following ACL reconstruction - study protocol for a randomized controlled trial".
Bo Bregenhof1,3* , Uffe Jørgensen1, Per Aagaard2, Nis Nissen3, Mark W. Creaby4, Jonas Bloch Thorlund2, Carsten Jensen3, Trine Torfing5 and Anders Holsgaard-Larsen1 Published: Trials. 2018; 19: 75. Published online 2018 Jan 26. doi: 10.1186/s13063-018-2448-3
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Targeted exercise | Other | Targeted exercise intervention |
|
| care as usual | No Intervention | home based exercises |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Targeted exercise | Other | 12 weeks of targeted and supervised exercise intervention vs. "care as usual" (home based exercises) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in isometric maximal knee flexor muscle strength | Change, pre- and post intervention using stabilized maximal isometric dynamometry (in Nm) | 12 weeks (intervention period) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in isometric knee extensor strength | Change, pre- and post intervention using stabilized maximal isometric dynamometry (in Nm) | 12 weeks (intervention period) |
| Change in isometric maximal hamstring to quadriceps strength ratio |
| Measure | Description | Time Frame |
|---|---|---|
| Gait analysis | Change, pre- and post intervention (12 weeks) using 3-dimensional Vicon motion analysis | 12 weeks (intervention period) |
| Counter movement jump | Change, pre- and post intervention (12 weeks) using 3-dimensional Vicon motion analysis (force Development) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anders Holsgaard-Larsen, ass.proff | Orthopaedic Research Unit, Institute of Clinical Research, SDU | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Orthopaedic Research Unit, Institute of Clinical Research, SDU | Odense | Region Syddanmark | 5000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29373984 | Derived | Bregenhof B, Jorgensen U, Aagaard P, Nissen N, Creaby MW, Thorlund JB, Jensen C, Torfing T, Holsgaard-Larsen A. The effect of targeted exercise on knee-muscle function in patients with persistent hamstring deficiency following ACL reconstruction - study protocol for a randomized controlled trial. Trials. 2018 Jan 26;19(1):75. doi: 10.1186/s13063-018-2448-3. |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| SAP | No | Yes | No | Statistical Analysis Plan | Sep 8, 2020 | Sep 8, 2020 | SAP_001.pdf |
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| ID | Term |
|---|---|
| D000070598 | Anterior Cruciate Ligament Injuries |
| D020233 | Gait Disorders, Neurologic |
| ID | Term |
|---|---|
| D007718 | Knee Injuries |
| D007869 | Leg Injuries |
| D014947 | Wounds and Injuries |
| D009461 | Neurologic Manifestations |
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Change, pre- and post intervention using stabilized maximal isometric dynamometry (in percentage)
| 12 weeks (intervention period) |
| Change in Self-perceived knee related function | Change, pre- and post intervention, using Patient reported outcomes (PROM) questionnaires (KOOS, Knee injury and Osteoarthritis Outcome Score, all subscales) | 12 weeks (intervention period) |
| 12 week intervention period |
| Change in One-leg jump for distance | Change, pre- and post intervention (12 weeks) in jumping distance (in cm). Simple functional test. | 12 week intervention period |
| Change in Quadriceps and hamstring morphologies | Change, pre- and post intervention (12 weeks) concerning volume, peak cross sectional area and length of muscle and tendon, using Magnetic resonance imaging (MRI) | 12 week intervention period |
| Change in Rate of force Development (RFD) in maximal quadriceps and hamstring strenght | Change, pre- and post intervention (12 weeks) using maximal isometric dynamometry (Nm/millisecond) | 12 week intervention period |
| Change in Self-perceived knee related function and symptoms | Change, pre- and post intervention (12 weeks) using Patient reported outcomes (PROM) questionnaires (IKDC, subjective knee evaluation form) | 12 week intervention period |
| D009422 |
| Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |