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Asthma is characterized by recurrent episodes of bronchospasm, bronchial hyperresponsiveness and chronic airway inflammation and pharmacological treatment for this condition is done with bronchodilators and anti-inflammatory.
Pharmacologic therapy has clinical efficacy in the control, but the patient often does not adhere adequately.
There is need for further research into non-pharmacological therapies for clinical asthma control and in turn the use of CPAP and bilevel pressure in the airways has shown beneficial effects on autonomic modulation and bronchial responsiveness leading to the hypothesis that these therapies also have effects on the BIE.The aim of this study is to evaluate the effect of these non-pharmacological therapies in several variables and especially the BIE.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| muscle training | Active Comparator | participants will breathing exercises for 20 min, then 40 min training with Threshold IMT therapy will be held in 7 sessions |
|
| bilevel positive airway pressure | Active Comparator | participants will breathing exercises for 20 min, then 40 min bilevel (IPAP and EPAP 12 = 8 cm H2O), the therapy will be held in 7 sessions |
|
| Continue Positive Airway Pressure | Active Comparator | participants will breathing exercises for 20 min, then 40 min CPAP (8 cm H2O) therapy will be held in 7 sessions |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| muscle training | Device |
| ||
| Measure | Description | Time Frame |
|---|---|---|
| Exhaled nitric oxide (part per billion) | assess the degree of inflammation of the respiratory system using expired fraction of nitric oxide before and after the different protocols applied | 5 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Heart Rate Variability | 20 minutes | |
| manovacuometry | 10 minutes | |
| Pulmonary function test |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maisi David Cabral | São Paulo | 01504-001 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29865929 | Derived | David MMC, Gomes ELFD, Mello MC, Costa D. Noninvasive ventilation and respiratory physical therapy reduce exercise-induced bronchospasm and pulmonary inflammation in children with asthma: randomized clinical trial. Ther Adv Respir Dis. 2018 Jan-Dec;12:1753466618777723. doi: 10.1177/1753466618777723. |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| D001986 | Bronchial Spasm |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| ID | Term |
|---|---|
| D045422 | Continuous Positive Airway Pressure |
| ID | Term |
|---|---|
| D011175 | Positive-Pressure Respiration |
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D013812 | Therapeutics |
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| Continue Positive Airway Pressure |
| Device |
|
| bilevel positive airway pressure | Device |
|
| 20 minutes |
| bioelectrical impedance | 10 minutes |
| Bronchoconstriction induced by stress | 30 minutes |
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D012138 |
| Respiratory Therapy |