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Deep Brain Stimulation represents the golden standard for surgical treatment of Parkinson's disease (PD), but it is not optimally effective for controlling every motor sign and adverse events are not so infrequent. Therefore,other approaches should be considered. New Approaches in MRI at 3T and long-term local field potential (LFP) recording are very important to target subthalamic nucleus (STN) and understand mechanisms of DBS on Parkinson Patients. This study aims at evaluating the safety and effectiveness of 3T MRI Compatible and LFP recordable deep brain stimulation on PD patients. The Chronically LFP recording using G106R is for two goals: 1) Evaluate the performance of long-term recordable neural simulation. 2) Study long-term clinical and electrophysiology effects of deep brain stimulation on STN.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MRI compatible and LFP recordable implantable stimulator | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 3T MRI compatible and LFP recordable G106R of Beijing Pins medical. | Device |
|
| Measure | Description | Time Frame |
|---|---|---|
| UPDRS part III | 1 month,3 months, 6 months and 12months | |
| Local Field Potential Recordings using G106R | 1 month,3 months, 6 months and 12months |
| Measure | Description | Time Frame |
|---|---|---|
| UPDRS part III | 1, 3 months of stimulation | |
| UPDRS part II | 1, 3 months stimulation | |
| Levodopa Equivalent Dose |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fumin Jia, PhD | Contact | 010-60736388 | ||
| Luming Li, PhD | Contact | 010-60736388 |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Tiantan Hospital | Recruiting | Beijing | Beijing Municipality | 100050 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38724231 | Derived | Zhang G, Yu H, Chen Y, Gong C, Hao H, Guo Y, Xu S, Zhang Y, Yuan X, Yin G, Zhang JG, Tan H, Li L. Neurophysiological features of STN LFP underlying sleep fragmentation in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2024 Nov 18;95(12):1112-1122. doi: 10.1136/jnnp-2023-331979. |
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Drug Therapy are definied as levodopa equivalent dose,which is devodopa containing or dopamine agonist containing medications |
| 1, 3 months stimulation |
| Local Field Potential Recordings using G106R | 1 month, 3 months |
| Peking Union Medical College Hospital | Recruiting | Beijing | Beijing Municipality | China |
|
| Qilu Hospital of Shandong University | Recruiting | Jinan | Shandong | 250012 | China |
|