Antibiotic Prophylaxis in Open Fractures

Antibiotic Prophylaxis With Ceftaroline for Type II and II Open Fractures: a Phase 4, Open-label, Prospective Clinical Trial

Prospective look at antibiotic prophylaxis with Ceftaroline in patients with type II and III open fractures

Determine if antibiotic prophylaxis with Ceftaroline in patients with type II and III open fractures is a safe and effective alternative to standard combination therapy

Inclusion Criteria:

• male or female >= 18 years old
• complete an informed consent
• patients are diagnosed with a type II or III open fracture

Exclusion Criteria:

• allergy to beta-lactam antibiotics prior to screening
• prior to enrollment: patients received 3 or more doses of antibiotic prophylaxis
• pregnant female
• inability to provide consent