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| Name | Class |
|---|---|
| Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | OTHER |
| Radboud University Medical Center | OTHER |
| Maasstad Hospital | OTHER |
| Amsterdam UMC, location VUmc |
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This study will prospectively assess the impact and relevance of several risk factors for children with severe acute asthma (SAA) or acute wheeze that have been identified in retrospective studies. Secondary we will assess short-term medical and psychosocial functioning in patient (and parents) admitted to a PICU for SAA/acute wheeze versus a control group admitted to a MC for SAA/acute wheeze.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PICU (= case group) | Children aged 2-18 years admitted to a Paediatric Intensive Care Unit in the Netherlands, with a diagnosis of acute wheeze or SAA. | ||
| MC (= control group) | Children aged 2-18 years admitted to a Medium Care in the Netherlands, with a diagnosis of acute wheeze or SAA. |
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| Measure | Description | Time Frame |
|---|---|---|
| Undertreatment in children admitted to a PICU with a diagnosis of SAA/acute wheeze | Undertreatment is defined as: Patient is not using inhaled corticosteroids (ICS), or Patient is using ICS < 7 days (counting from moment of admission to emergency department) according to treatment plan, or Patient is not using ICS according tot treatment plan. | Within the time of admission on the PICU/MC, preferably within 48 hours and during follow up after 3-6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Exposure to triggers (single or combined) | Pollution/airborne particulate matter (PM10), sensitization/allergen exposure, cigarette smoke exposure (measured by cotinine in urine), presence and type of virus in upper airway tract | Within the time of admission on the PICU/MC, preferably within 24 hours |
| Socio-economic status |
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Inclusion Criteria:
Exclusion Criteria:
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Children aged 2-18 years admitted to a Medium Care or Paediatric Intensive Care Unit in the Netherlands, with a diagnosis of acute wheeze or SAA.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Erasmus MC | Rotterdam | South Holland | 3000WB | Netherlands |
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| OTHER |
| UMC Utrecht | OTHER |
| University Medical Center Groningen | OTHER |
| Amphia Hospital | OTHER |
| Rijnstate Hospital | OTHER |
| Tergooi Hospital | OTHER |
| Maastricht University Medical Center | OTHER |
| Leiden University Medical Center | OTHER |
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| Within the time of admission on the PICU/MC |
| Frequency of previous asthma-related hospital admissions and/or PICU admissions. | Within the time of admission on the PICU/MC and during follow up after 3-6 months |
| Severity of disease, defined using the GINA criteria for stepwise management of asthma. | Within the time of admission on the PICU/MC, preferably within 48 hours and during follow up after 3-6 months |
| Distribution of ADRB2-receptor polymorphisms compared to non-SAA population. | Through study completion, preferably within the time of admission on the PICU/MC |