This randomized multi-center study is intended to compare different coatings on stents for treatment of lesions of the above-the-knee femoropopliteal artery.

Inclusion Criteria:

• One de novo or restenosed artherosclerotic lesion with ≥ 50% diameter stenosis
• Symptoms of peripheral arterial disease (Rutherford 2-4)

Exclusion Criteria:

• Pregnant, breastfeeding, or planning to become pregnant in the next 5 years
• Less than 18 years old
• Medical condition or disorder that would limit life expectancy to less than 12 months or that may cause noncompliance with the protocol or confound the data analysis
• Previous stent in the study vessel