A Study to Assess the pharmacoMRI Effects of AUT00206 in Healthy Males

A Phase 1, Single-centre, Double-blind, Placebocontrolled Crossover Study to Assess the pharmacoMRI Effects of AUT00206 in Healthy Male Participants

A Phase 1, Single-centre, Double-blind, Placebo controlled Crossover Study to Assess the pharmacoMRI Effects of AUT00206 in Healthy Male Participants

Inclusion Criteria:

• Male aged 18 to 45 years, inclusive at Visit 1.
• Healthy on the basis of medical history, psychiatric history, physical examination, vital signs, 12-lead electrocardiogram (ECG), haematology, blood chemistry and urinalysis within 6 weeks of Visit 2.
• Right-handed.
• Not a regular smoker (maximum 5 cigarettes per week or equivalent).

Exclusion Criteria:

• History of, or current condition of, migraine headaches or has undergone operations to the head.
• History of significant claustrophobia.