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| Name | Class |
|---|---|
| Air Force Military Medical University, China | OTHER |
| Shengjing Hospital | OTHER |
| Qilu Hospital of Shandong University | OTHER |
| Second Xiangya Hospital of Central South University |
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This clinical study aims to investigate the anti-HPA antibodies caused neonatal alloimmune thrombocytopenia in Chinese pregnant women. The survey and data collect will help form an appropriate clinical screening procedure
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group | Pregnant women with anti-HPA antibody negative from the same hospital, the same race, and the same gravidity and parity, who are admitted at the same time. |
| |
| Experimental Group | pregnant women with anti-HPA antibody positive |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard clinical treatment, including intravenous immunoglobulin and/or platelet transfusion | Procedure | Observational study. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The positive rate of anti-HPA antibody | Up to one and a half years after the study completed | |
| The morbidity of NAIT | Up to one and a half years after the study completed |
| Measure | Description | Time Frame |
|---|---|---|
| Antigenic specificity of anti-HPA antibodies | Up to one and a half years after the study completed | |
| Association of anti-HPA antibody with HLA genotype as assessed by Chi-square test | Up to one and a half years after the study completed |
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Inclusion Criteria:
Exclusion Criteria:
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Pregnant Chinese women and their new borns
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Li Chen | Contact | 0118615178936688 | chenli200401@163.com |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28859622 | Derived | Chen L, Liu Z, Liu T, Ma X, Rao M, Wang Y, Sun B, Yin W, Zhang J, Yan B, Li X, Wang Q, Zhang L, Wen J, Liu F, Wang P, Wei Y, Huang Y, Wu J, Guo Y, Kang Y, Song X, Liu X, Zhang G, Xie T, Chen Y, Zeng X, Li Z. Neonatal alloimmune thrombocytopenia caused by anti-HPA antibodies in pregnant Chinese women: a study protocol for a multicentre, prospective cohort trial. BMC Pregnancy Childbirth. 2017 Aug 31;17(1):281. doi: 10.1186/s12884-017-1453-y. |
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| OTHER |
| LanZhou University | OTHER |
| The First Affiliated Hospital of Bengbu Medical University | OTHER |
| The Affiliated Hospital Of Guizhou Medical University | OTHER |
| Sir Run Run Shaw Hospital | OTHER |
| Jilin University | OTHER |
| First Affiliated Hospital of Xinjiang Medical University | OTHER |
| People's Hospital of Xinjiang Uygur Autonomous Region | OTHER |
| Second Affiliated Hospital of Nanchang University | OTHER |
| Guangzhou First People's Hospital | OTHER |
| The Affiliated Hospital Of Southwest Medical University | OTHER |
| Beijing Chao Yang Hospital | OTHER |
| Qingdao University | OTHER |
| Peking University First Hospital | OTHER |
| RenJi Hospital | OTHER |
| First Affiliated Hospital of Harbin Medical University | OTHER |
| MCH Hospital of Yinchuan City | UNKNOWN |
| Henan Provincial People's Hospital | OTHER |
| Third Affiliated Hospital, Sun Yat-Sen University | OTHER |
| The First Affiliated Hospital of Guangdong Pharmaceutical University | OTHER |
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| The relationship between the titer of anti-HPA antibody and clinical symptom severity in NAIT as assessed by Spearman Correlation assay | Up to one and a half years after the study completed |
| ID | Term |
|---|---|
| D054098 | Thrombocytopenia, Neonatal Alloimmune |
| ID | Term |
|---|---|
| D013921 | Thrombocytopenia |
| D001791 | Blood Platelet Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D000095542 | Cytopenia |
| D007232 | Infant, Newborn, Diseases |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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