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| Name | Class |
|---|---|
| Université du Québec a Montréal | OTHER |
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This randomized, cross-over study aims at describing the effect of pursed lip breathing on exercise-induced dyspnea and exercise capacity in patients with interstitial lung disease.
The use of pursed lip breathing (PLB) to improve exercise tolerance in COPD patients has been widely documented. However, its efficacy in patients with interstitial lung disease (ILD) has yet to be confirmed. This study aims to determine if PLB improves perceived exertion and exercise capacity during a six-minute walk test (6MWT) in patients with ILD. To achieve this, a prospective randomized crossover trial will be performed, in which patients with ILD and restrictive ventilatory defect will be recruited via the ILD clinic of Hôpital Notre-Dame. The study will be performed in a single visit, on the day where patients attend a routine physician-prescribed follow-up 6MWT. Patients will be asked to perform a total of two 6MWT. Patients will be randomized to perform the first test with or without using PLB, and the order will be reversed for the second test, with patients serving as their own control. During tests, ventilatory variables will be continuously measured using a portable metabolic cart. The observed parameters will be: perceived exertion using the Modified-Borg Scale, respiratory rate, minute-ventilation, heart rate, peripheral oxygen saturation, and 6-minute walk distance (6MWD). It is expected that the use of PLB will be associated with a decrease of at least one unit on the Modified Borg Scale, which would be clinically significant. Moreover, it is expected that the decrease in dyspnea with PLB will be related to a decrease in respiratory rate minute ventilation during 6MWT. The clinical impact of this study could be significant as therapies allowing the improvement of dyspnea in patients with ILD are scarce.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pursed lip breathing | Experimental | In this arm, patients will be asked to perform a six-minute walking test while continuously using the pursed lip breathing technique. |
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| Usual breathing | No Intervention | In this control arm, patients will be asked to perform a six-minute walking test while breathing normally. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pursed lip breathing | Behavioral | Pursed lip breathing will be taught to the participants following the chronic obstructive pulmonary disease (COPD) Foundation recommendations:
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| Measure | Description | Time Frame |
|---|---|---|
| Exertional dyspnea | Patient-reported dyspnea will be measured using the Borg scale | On the day of randomization |
| Measure | Description | Time Frame |
|---|---|---|
| Six-minute walking distance | On the day of randomization | |
| Oxygen uptake (ml/min) | Non-invasive real-time measurements will be performed using a portable metabolic cart system. | On the day of randomization, at each minute of the 6-minute walking test |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bruno-Pierre Dubé, MD | Centre hospitalier de l'Université de Montréal (CHUM) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHUM (Notre-Dame Hospital) | Montreal | Quebec | H2L 4M1 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30624373 | Derived | Parisien-La Salle S, Abel Rivest E, Boucher VG, Lalande-Gauthier M, Morisset J, Manganas H, Poirier C, Comtois AS, Dube BP. Effects of Pursed Lip Breathing on Exercise Capacity and Dyspnea in Patients With Interstitial Lung Disease: A RANDOMIZED, CROSSOVER STUDY. J Cardiopulm Rehabil Prev. 2019 Mar;39(2):112-117. doi: 10.1097/HCR.0000000000000387. |
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| ID | Term |
|---|---|
| D017563 | Lung Diseases, Interstitial |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| Carbon dioxide output (ml/min) | Non-invasive real-time measurements will be performed using a portable metabolic cart system. | On the day of randomization, at each minute of the 6-minute walking test |
| Respiratory rate (br/min) | Non-invasive real-time measurements will be performed using a portable metabolic cart system. | On the day of randomization, at each minute of the 6-minute walking test |
| Tidal volume (ml) | Non-invasive real-time measurements will be performed using a portable metabolic cart system. | On the day of randomization, at each minute of the 6-minute walking test |
| Minute-ventilation (l/min) | Non-invasive real-time measurements will be performed using a portable metabolic cart system. | On the day of randomization, at each minute of the 6-minute walking test |
| Peripheral oxygen saturation (%) | Non-invasive real-time measurements will be performed using a portable metabolic cart system. | On the day of randomization, at each minute of the 6-minute walking test |