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| Name | Class |
|---|---|
| University Hospital, Akershus | OTHER |
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The overall aim of the study is to assess the effect of school-based Human Papillomavirus (HPV) vaccination by comparing type-specific HPV prevalence between vaccinated and non-vaccinated women born in 1997. Women born in 1997, residence to Norway in 2009 (the year of vaccine initiation of the 1997-cohort) are invited to participate in the study.
This cohort is amongst the first that was offered HPV vaccine in an organized vaccination programme globally. The women will be recruited through Facebook ads. The study will enable us to measure differences in the prevalence of HPV types in vagina and the mouth between vaccinated and non-vaccinated young women in Norway.
The womens vaccination status will be validated by linkage to the Norwegian Immunisation Registry (SYSVAK) and their residence status will be validated through linkage to the Norwegian Population Registry.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vaccinated | Women born in 1997, resident to Norway in 2009, vaccinated by the quadrivalent HPV vaccine. Interventions:
|
| |
| Un-vaccinated | Women born in 1997, resident to Norway in 2009, not vaccinated by the quadrivalent HPV vaccine Interventions:
|
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Self sample from vagina | Procedure | Self sample using The Rover's Evalyn Brush |
|
| Measure | Description | Time Frame |
|---|---|---|
| Vaginal and oral HPV-6, HPV-11, HPV-16 and HPV-18 prevalence | The differences in HPV types prevalence among vaccinees and non-vaccinees. HPV types will be assessed individually and combined. | Within 2 months after self-collection of specimens |
| Measure | Description | Time Frame |
|---|---|---|
| Description of oral and vaginal overall genotype distribution among vaccinated and non-vaccination participants | Within 2 months after self-collection of specimens |
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Inclusion Criteria:
Exclusion Criteria:
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Women resident to Norway in 2009
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| Name | Affiliation | Role |
|---|---|---|
| Espen Enerly, Dr Scient | Oslo University Hospital | Principal Investigator |
| Giske Ursin, Dr.Med | Oslo University Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oslo University Hospital, Cancer Registry of Norway | Oslo | 0379 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31830145 | Background | PLOS ONE Staff. Correction: An observational study comparing HPV prevalence and type distribution between HPV-vaccinated and -unvaccinated girls after introduction of school-based HPV vaccination in Norway. PLoS One. 2019 Dec 12;14(12):e0226706. doi: 10.1371/journal.pone.0226706. eCollection 2019. | |
| 31600341 | Result |
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| ID | Term |
|---|---|
| D002578 | Uterine Cervical Dysplasia |
| D002583 | Uterine Cervical Neoplasms |
| D009959 | Oropharyngeal Neoplasms |
| ID | Term |
|---|---|
| D011230 | Precancerous Conditions |
| D009369 | Neoplasms |
| D002577 | Uterine Cervical Diseases |
| D014591 | Uterine Diseases |
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| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
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Self samples from vagina and the oral cavity
| Self sample from the oral cavity | Procedure | Self sample using COPAN FloqSwab |
|
| Questionnaire | Other | Questionnaire about vaccination status and sexual behaviour |
|
| Enerly E, Flingtorp R, Christiansen IK, Campbell S, Hansen M, Myklebust TA, Weiderpass E, Nygard M. An observational study comparing HPV prevalence and type distribution between HPV-vaccinated and -unvaccinated girls after introduction of school-based HPV vaccination in Norway. PLoS One. 2019 Oct 10;14(10):e0223612. doi: 10.1371/journal.pone.0223612. eCollection 2019. |
| D005831 |
| Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D014594 | Uterine Neoplasms |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D010610 | Pharyngeal Neoplasms |
| D010039 | Otorhinolaryngologic Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D010608 | Pharyngeal Diseases |
| D009057 | Stomatognathic Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |