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Patients with metastatic spinal cord compression (MSCC) are treated with different options according to the life expectancy. Survival and surgical outcome can be influenced by surgical timing in MSCC patients treated with palliative decompression.
MSCC patients who underwent palliative decompression after January 2012 in National Taiwan University Hospital (NTUH) were divided into the preoperative motor function intact group (Group A) and motor deficit group (Group B). The motor deficit group was subdivided into operation within 48 hours (Group B1), and after 48 hours (Group B2). All patients underwent palliative decompression and posterior stabilization. Investigators did wide laminectomy for tumor invading the vertebral body, and debulking surgery for tumor destructing the posterior column of the spine. Investigators retrospectively reviewed all patient records, including patient demographics, prognostic factors for survival (Kaplan-Meier survival analysis), neurological outcome (Frankel grade), primary tumor, complications, and relevance of Tomita and Tokuhashi scores.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Motor function intact group: received palliative decompression |
| |
| Group B1 | motor deficit group: received palliative decompression within 48 hours after symptoms occured |
| |
| Group B2 | motor deficit group: received palliative decompression 48 hours after symptoms occured |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Palliative Decompression | Other | palliative decompression to MSCC patients: before motor deficit (Group A), within 48 hours after motor deficit (Group B1), 48 hours after motor deficit (Group B2) |
| Measure | Description | Time Frame |
|---|---|---|
| survival rate | 5 years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with metastatic spinal cord compression (MSCC) who underwent palliative decompression.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shu-Hua Yang, M.D., Ph.D. | Contact | 886-2-23123456 | 63981 | 005964@ntuh.gov.tw |
| Name | Affiliation | Role |
|---|---|---|
| Shu-Hua Yang, M.D., Ph.D. | National Taiwan University Hospital | Study Chair |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16205345 | Background | Tokuhashi Y, Matsuzaki H, Oda H, Oshima M, Ryu J. A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976). 2005 Oct 1;30(19):2186-91. doi: 10.1097/01.brs.0000180401.06919.a5. | |
| 11224867 | Background | Tomita K, Kawahara N, Kobayashi T, Yoshida A, Murakami H, Akamaru T. Surgical strategy for spinal metastases. Spine (Phila Pa 1976). 2001 Feb 1;26(3):298-306. doi: 10.1097/00007632-200102010-00016. |
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| ID | Term |
|---|---|
| D009362 | Neoplasm Metastasis |
| D013117 | Spinal Cord Compression |
| ID | Term |
|---|---|
| D009385 | Neoplastic Processes |
| D009369 | Neoplasms |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D013119 | Spinal Cord Injuries |
| D014947 | Wounds and Injuries |