This is a 5-year, longitudinal, observational study of patients with PBC designed to specifically address important clinical questions that remain incompletely answered from registration trials. In addition to the study database, a bio specimen repository will also be included so that translational studies of genomics and biomarkers of response may be performed.

Inclusion Criteria:

• Adult patients (age 18 or older) being treated or managed for PBC

Exclusion Criteria:

• Inability to provide written informed consent
• Simultaneous enrollment in another prospective registry or clinical trial or study where PBC treatment outcomes are reported, except where approved or conducted as an adjunct project of TARGET-PBC

adults with PBC who are being seen specifically to address this disease process