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This study is a randomized, double-blind, and sham-controlled trial to examine the effects of transcranial magnetic stimulation on the brain of health individuals.
The efficacy of repetitive transcranial magnetic stimulation on the brain will be assessed by multimodal neuroimaging in healthy individuals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| rTMS + Wash-out period + Sham | Active Comparator |
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| Sham + Wash-out period + rTMS | Sham Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neurostar TMS Therapy System, NeuroStar XPLOR System | Device | Repetitive transcranial magnetic stimulation |
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| Measure | Description | Time Frame |
|---|---|---|
| Metabolic brain changes in magnetic resonance imaging by computational approaches | after 5 sessions (1 session/day) equals 5 days |
| Measure | Description | Time Frame |
|---|---|---|
| Functional brain changes in magnetic resonance imaging by computational approaches | after 5 sessions (1 session/day) equals 5 days | |
| Standardized scores on a neuropsychological test battery | after 5 sessions (1 session/day) equals 5 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ewha Womans University Mokdong Hospital | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35951113 | Derived | Hong H, Kim RY, Song Y, Suh C, Lee H, Lyoo IK, Yoon S, Lim SM, Lee S. Genetic profile for dopamine signaling predicts brain functional reactivity to repetitive transcranial magnetic stimulation. Eur Arch Psychiatry Clin Neurosci. 2023 Feb;273(1):99-111. doi: 10.1007/s00406-022-01436-2. Epub 2022 Aug 11. |
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| Analysis of EEG activity | after 5 sessions (1 session/day) equals 5 days |