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To develop machine learning algorithms for the identification of future development of cardiovascular and metabolic disease
The MILESTONE trial is retrospective and data review study with health checkup data from the National Health Insurance Services(NHIS) in Korea. The data will be included general health examination for individuals , type of health insurance, medical bill details, medical histories, treatment and prescriptions about 514,795 individuals who were over 40 years old.
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| Measure | Description | Time Frame |
|---|---|---|
| Accuracy in prediction of development of cardiovascular and metabolic disease using machine learning algorithm | 6months |
| Measure | Description | Time Frame |
|---|---|---|
| Accuracy in prediction of development of cardiovascular and metabolic disease using logistic regression analysis | 6months | |
| Accuracy in prediction of development of cardiovascular and metabolic disease using Framingham risk score | 6months |
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Inclusion Criteria:
Exclusion Criteria:
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The data which is health checkup record about 510,000 Subjects between 2002 and 2013 from National Health Insurance Service (NHIS) in South Korea.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hyuk-Jae Chang, PhD | Contact | hjchang@yuhs.ac | ||
| In-Jeong Cho | Contact | injeongcho@yuhs.ac |
| Name | Affiliation | Role |
|---|---|---|
| Hyuk-Jae Chang, PhD | Yonsei Univerity | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yonsei University Severance Hospital | Recruiting | Seoul | 102-752 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31456363 | Derived | Cho IJ, Sung JM, Kim HC, Lee SE, Chae MH, Kavousi M, Rueda-Ochoa OL, Ikram MA, Franco OH, Min JK, Chang HJ. Development and External Validation of a Deep Learning Algorithm for Prognostication of Cardiovascular Outcomes. Korean Circ J. 2020 Jan;50(1):72-84. doi: 10.4070/kcj.2019.0105. Epub 2019 Aug 19. | |
| 29150537 | Derived |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D008659 | Metabolic Diseases |
| ID | Term |
|---|---|
| D009750 | Nutritional and Metabolic Diseases |
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| Cho IJ, Sung JM, Chang HJ, Chung N, Kim HC. Incremental Value of Repeated Risk Factor Measurements for Cardiovascular Disease Prediction in Middle-Aged Korean Adults: Results From the NHIS-HEALS (National Health Insurance System-National Health Screening Cohort). Circ Cardiovasc Qual Outcomes. 2017 Nov;10(11):e004197. doi: 10.1161/CIRCOUTCOMES.117.004197. |