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| Name | Class |
|---|---|
| Aarhus University Hospital | OTHER |
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Neuromas are frequent after trauma and surgery, including amputation and can be identified by high-resolution ultrasound. The role of neuromas as the cause of neuropathic pain is uncertain. The investigators therefore wish to explore if spontaneous and evoked pain will be relieved by injection of local anesthetics near painful neuromas in subjects with peripheral nerve injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lidocaine | Active Comparator | Lidocaine 2 ml injection with 2% Adrenaline |
|
| Isotonic Saline | Placebo Comparator | Isotonic Saline 2 ml Injection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lidocaine | Drug |
| ||
| Isotonic Saline |
| Measure | Description | Time Frame |
|---|---|---|
| Spontaneous pain on numerical rating scale (NRS 0-10) | The participant will be asked about spontaneous pain | 15 minutes after injection |
| Evoked pain on numerical rating scale (NRS 0-10) | 15 minutes after injection |
| Measure | Description | Time Frame |
|---|---|---|
| Brush allodynia | Assesment of area (cm^2) using a SOMEDIC brush | 15 minutes after injection |
| Pinprick hyperalgesia | Assesment of area (cm^2) using a von Frey filament (60 g) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Danish Pain Research Center, Aarhus University Hospital | Aarhus | 8000 | Denmark |
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| ID | Term |
|---|---|
| D009437 | Neuralgia |
| D009463 | Neuroma |
| ID | Term |
|---|---|
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D008012 | Lidocaine |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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|
| 15 minutes after injection |
| Cold allodynia | Assesment of area (cm^2) using a roll (20 degrees celcius) | 15 minutes after injection |
| Heat allodynia | Assesment of area (cm^2) using a roll (40 degrees celcius) | 15 minutes after injection |
| D009461 |
| Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D018317 | Nerve Sheath Neoplasms |
| D009380 | Neoplasms, Nerve Tissue |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| Aniline Compounds |
| D000588 | Amines |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |