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The aim of this study is to assess the clinical effect of aPDT on deep caries in permanent teeth. Half of the deep caries will receive aPDT disinfect in restorative treatment procedure, while the other half will receive sodium 0.9% saline in restorative treatment procedure.
The aim of the proposed study is to assess the clinical effect of antimicrobial photodynamic therapy (aPDT) using LED on dentin with deep caries in permanent teeth. Permanent teeth with deep carious lesions on the occlusal surface indicated for restorative treatment will be randomly allocated to two groups: Group 1 -Control after incomplete caries removal, washed with sodium 0.9% saline; Group 2 - PDT + CH after incomplete caries removal, disinfect the residual dentin with PDT(LED + O-Toluidine Blue). Dentin samples will be collected before and after disinfect for microbiological analysis. Then the teeth will be capped with CH and restored using resin with clinical and radiographic follow up at 6, 12 and 24 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Experimental | Local anesthesia, rubber dam isolation, remove caries incompletely, microbiological sample with otoscope curette, dentin washed with sodium 0.9% saline, sampling again. Indirect pulp treatment with calcium hydroxide(CH). Restoration with resin(Z350,3M). Follow up at 6, 12 and 24 months. |
|
| PDT+CH | Experimental | Local anesthesia, rubber dam isolation, remove caries incompletely, microbiological sample with otoscope curette, disinfect the remaining dentin with antimicrobial photodynamic therapy (DENFOTEX PADplus), sampling again. Indirect pulp treatment with calcium hydroxide(CH). Restoration with resin(Z350,3M). Follow up at 6, 12 and 24 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Local anesthesia and rubber dam isolation | Procedure | Local anesthesia was performed. Tooth was isolated using a rubber dam isolation in order to collect the dentin samples. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Quantification of bacteria by colony counting | Quantification of total bacteria | 2 days after dentin collection |
| Measure | Description | Time Frame |
|---|---|---|
| Tooth Pain | Patients reported the presence or absence of tooth pain | 1 day and 6, 12, 24 months |
| Restoration Quality | The quality of restoration was evaluated through the absence of radiographic radiolucent area |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xiuqing Wang, Bachelor | Contact | +8613658079779 | 1245451840@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| Xiaojing Huang, PhD | School and Hospital of stomatology, Fujian Medical University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| School and Hospital of Stomatology, Fujian Medical University | Recruiting | Fuzhou | Fujian | China |
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| Incomplete caries removal and microbiological samples collection | Procedure | Partial carious tissue was removed with conventional dentinal curette and collection of dentin with a spoon (1#) was performed. |
|
| Dentin washed with sodium 0.9% saline | Procedure | The remaining dentin was dipped in sodium 0.9% saline for 2min. |
|
| Antimicrobial Photodynamic Therapy | Procedure | The remaining dentin was disinfected with aPDT for 2 min. |
|
| Microbiological samples collection and Indirect pulp treatment | Procedure | A new dentin collection was performed after this treatment at another site of the cavity. Then teeth were conventionally restored using the following materials: calcium hydroxide lining material and resin (Z350,3M). |
|
| 1 day and 6, 12, 24 months |
| ID | Term |
|---|---|
| D003731 | Dental Caries |
| ID | Term |
|---|---|
| D017001 | Tooth Demineralization |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D000772 | Anesthesia, Local |
| D012964 | Sodium |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D000765 | Anesthesia, Conduction |
| D000758 | Anesthesia |
| D000760 | Anesthesia and Analgesia |
| D008672 | Metals, Alkali |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D019565 | Metals, Light |
| D008670 | Metals |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D017670 | Sodium Compounds |
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