An Open Label, Single Arm, Multicenter, Safety Study of Atezolizumab in Locally Advanced or Metastatic Urothelial or Non-Urothelial Carcinoma of the Urinary Tract
An Open Label, Single Arm, Multicenter, Safety Study of Atezolizumab in Locally Advanced or Metastatic Urothelial or Non-Urothelial Carcinoma of the Urinary Tract
This Phase IIIb, multicenter study will assess the safety of atezolizumab as second- to fourth-line treatment for participants with locally advanced or metastatic urothelial or non-urothelial cancer of the urinary tract in addition to evaluate the efficacy of atezolizumab and potential tumor biomarkers associated with atezolizumab.
Inclusion Criteria:
Exclusion Criteria:
Treatment with more than three prior lines of systemic therapy for inoperable, locally advanced or metastatic urothelial or non-urothelial carcinoma of the urinary tract
Treatment with any other investigational agent or participation in another clinical trial with therapeutic intent within 4 weeks prior to study treatment initiation
Malignancies other than the one studied in this protocol within 5 years prior to Cycle 1, Day 1
Evidence of significant uncontrolled concomitant disease that could affect compliance with the protocol
Significant renal disorder indicating a need for renal transplant
Caba, C1118AAT, Argentina
Ciudad Autonoma Buenos Aires, C1284AEB, Argentina
Salzburg, 5020, Austria
Vienna, 1090, Austria
Sofia, 1527, Bulgaria
Nanjing, 210008, China
Erlangen, 91054, Germany
Göttingen, 37075, Germany
Hanover, 30625, Germany
Thermi Thessalonikis, 570 01, Greece
Budapest, 1062, Hungary
Szeged, 6720, Hungary
Dublin, D24 NR0A, Ireland
Naples, Campania 80131, Italy
Meldola, Emilia-Romagna 47014, Italy
Udine, Friuli Venezia Giulia 33100, Italy
Genoa, Liguria 16132, Italy
Kaunas, 50009, Lithuania
?ory, 44-240, Poland
Poznan, 60-570, Poland
Cluj-Napoca, 400015, Romania
Moscow, Moscow Oblast 115478, Russia
Moscow, Moscow Oblast 125248, Russia
Palma de Mallorca, Balearic Islands 07014, Spain
Santiago de Compostela, LA Coruña 15706, Spain
Navarra, Navarre 31008, Spain
Oviedo, Principality of Asturias 33011, Spain
San Cristóbal de La Laguna, Tenerife 38320, Spain
Madrid, 28050, Spain
Bern, 3010, Switzerland