Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid... | NCT02928224 | Trialant

Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid... | NCT02928224 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Key Inclusion Criteria:

Age ≥ 18 years at time of informed consent

Histologically- or cytologically-confirmed CRC that is metastatic

Presence of BRAFV600E in tumor tissue as previously determined by a local assay at any time prior to Screening or by the central laboratory

Progression of disease after 1 or 2 prior regimens in the metastatic setting

Evidence of measurable or evaluable non-measurable disease per RECIST, v1.1

Adequate bone marrow, cardiac, kidney and liver function

Able to take oral medications

Female patients are either postmenopausal for at least 1 year, are surgically sterile for at least 6 weeks, or must agree to take appropriate precautions to avoid pregnancy from screening through follow-up if of childbearing potential

Males must agree to take appropriate precautions to avoid fathering a child from screening through follow-up

Key Exclusion Criteria:

Prior treatment with any RAF inhibitor, MEK inhibitor, cetuximab, panitumumab or other epidermal growth factor receptor (EGFR) inhibitors

Prior irinotecan hypersensitivity or toxicity that would suggest an inability to tolerate irinotecan 180 mg/m2 every 2 weeks

Symptomatic brain metastasis or leptomeningeal disease

History or current evidence of retinal vein occlusion or current risk factors for retinal vein occlusion (e.g., uncontrolled glaucoma or ocular hypertension, history of hyperviscosity or hypercoagulability syndromes)

Known history of acute or chronic pancreatitis

History of chronic inflammatory bowel disease or Crohn's disease requiring medical intervention (immunomodulatory or immunosuppressive medications or surgery) ≤12 months prior to randomization

Uncontrolled blood pressure despite medical treatment

Impaired GI function or disease that may significantly alter the absorption of encorafenib or binimetinib (e.g., ulcerative diseases, uncontrolled vomiting, malabsorption syndrome, small bowel resection with decreased intestinal absorption)

Concurrent or previous other malignancy within 5 years of study entry, except cured basal or squamous cell skin cancer, superficial bladder cancer, prostate intraepithelial neoplasm, carcinoma in-situ of the cervix, or other noninvasive or indolent malignancy

History of thromboembolic or cerebrovascular events ≤ 6 months prior to starting study treatment, including transient ischemic attacks, cerebrovascular accidents, deep vein thrombosis or pulmonary emboli

Concurrent neuromuscular disorder that is associated with the potential of elevated creatine (phosphor)kinase (CK) (e.g., inflammatory myopathies, muscular dystrophy, amyotrophic lateral sclerosis, spinal muscular atrophy)

Residual common terminology criteria for adverse events (CTCAE) ≥ Grade 2 toxicity from any prior anticancer therapy, with the exception of Grade 2 alopecia or Grade 2 neuropathy

Known history of HIV infection

Active hepatitis B or hepatitis C infection

Known history of Gilbert's syndrome

Known contraindication to receive cetuximab or irinotecan at the planned doses

Mayo Clinic Hospital

Phoenix, Arizona 85054, United States

Mayo Clinic

Phoenix, Arizona 85054, United States

Mayo Clinic

Scottsdale, Arizona 85259, United States

City of Hope (City of Hope National Medical Center, City of Hope Medical Center)

Duarte, California 91010, United States

Compassionate Care Research Group, Inc. at Compassionate Cancer Care Medical Group, Inc.

Fountain Valley, California 92708, United States

Keck Hospital of USC - Norris Healthcare Center (HC3)

Los Angeles, California 90033, United States

Keck Hospital of USC

Los Angeles, California 90033, United States

LAC+USC Medical Center

Los Angeles, California 90033, United States

Norris Healthcare Center 3 (HC3)

Los Angeles, California 90033, United States

USC Eye Institute

Los Angeles, California 90033, United States

USC/Norris Comprehensive Cancer Center

Los Angeles, California 90033, United States

Hoag Memorial Hospital Presbyterian

Newport Beach, California 92663, United States

Harvard Eye Associates

Orange, California 92868, United States

Rocky Mountain Lions Eye Institute

Aurora, Colorado 80045, United States

University of Colorado Cancer Center - Anschutz Cancer Pavilion

Aurora, Colorado 80045, United States

University of Colorado Denver CTO (CTRC)

Aurora, Colorado 80045, United States

University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP)

Aurora, Colorado 80045, United States

University of Colorado Hospital Inpatient Pavillion'

Aurora, Colorado 80045, United States

Smilow Cancer Hospital at Yale - New Haven

New Haven, Connecticut 06510, United States

Temple Medical Center

New Haven, Connecticut 06510, United States

Yale University, Yale Cancer Center

New Haven, Connecticut 06520, United States

Smilow Cancer Hospital Care Center at North Haven

North Haven, Connecticut 06473, United States

The Lennar Foundation Medical Center

Coral Gables, Florida 33146, United States

Broward Health Medical Center

Fort Lauderdale, Florida 33316, United States

Dr. Clayton Berger (opthalmology)

Fort Lauderdale, Florida 33316, United States

Mehmet F. Hepgur, MD - Broward Health Medical Center

Fort Lauderdale, Florida 33316, United States

Mayo Clinic Florida

Jacksonville, Florida 32224, United States

Sylvester Comprehensive Cancer Center/UMHC

Miami, Florida 33136, United States

Sylvester at Kendall

Miami, Florida 33176, United States

Illinois CancerCare- Bloomington

Bloomington, Illinois 61704, United States

University of Chicago Medical Center

Chicago, Illinois 60637, United States

Illinois CancerCare- Galesburg

Galesburg, Illinois 61401, United States

University of Chicago Comprehensive Cancer Center at Silver Cross Hospital

New Lenox, Illinois 60451, United States

The University of Chicago Medicine Center for Advanced Care Orland Park

Orland Park, Illinois 60462, United States

Illinois CancerCare- Ottawa

Ottawa, Illinois 61350, United States

Illinois Cancer Care, PC

Peoria, Illinois 61615, United States

Illinois Eye Center

Peoria, Illinois 61615, United States

Carle Cancer Center

Urbana, Illinois 61801, United States

Indiana University Health Hospital

Indianapolis, Indiana 46202, United States

Indiana University Health Melvin and Bren Simon Cancer Center

Indianapolis, Indiana 46202, United States

Investigational Drug Services IUHSCC

Indianapolis, Indiana 46202, United States

Sidney &Lois Eskenazi Hospital

Indianapolis, Indiana 46202, United States

IU Health Springmill

Indianapolis, Indiana 46290, United States

Baptist Health Floyd Cancer Center

New Albany, Indiana 47150, United States

University of Iowa Hospitals and Clinics

Iowa City, Iowa 52242, United States

The University of Kansas Clinical Research Center

Fairway, Kansas 66205, United States

The University of Kansas Hospital

Kansas City, Kansas 66160, United States

KU Eye

Prairie Village, Kansas 66208, United States

The University of Kansas Cancer Center and Medical Pavilion

Westwood, Kansas 66205, United States

The University of Kansas Cancer Center, Investigational Drug Services

Westwood, Kansas 66205, United States

Ochsner Clinic Foundation

New Orleans, Louisiana 70121, United States

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Baltimore, Maryland 21287, United States

The Investigational Drug Pharmacy (IDS) in the Sidney Kimmel Cancer Center at Johns Hopkins

Baltimore, Maryland 21287, United States

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Baltimore, Maryland 21287, United States

Massachusetts General Hospital

Boston, Massachusetts 02114, United States

Ophthalmic Consultants of Boston Inc

Boston, Massachusetts 02114, United States

Brigham & Women's Hospital

Boston, Massachusetts 02115, United States

Dana-Farber Cancer Institute (DFCI)

Boston, Massachusetts 02215, United States

Dana-Farber Cancer Institute

Boston, Massachusetts 02215, United States

Mayo Clinic

Rochester, Minnesota 55905, United States

Siteman Cancer Center - St Peters

City of Saint Peters, Missouri 63376, United States

Siteman Cancer Center - West County

Creve Coeur, Missouri 63141, United States

SSM Health Saint Louis University Hospital

St Louis, Missouri 63104, United States

Barnes Jewish Hospital

St Louis, Missouri 63110, United States

Saint Louis University

St Louis, Missouri 63110, United States

SSM Health Saint Louis University Hospital

St Louis, Missouri 63110, United States

Washington University Infusion Center Pharmacy

St Louis, Missouri 63110, United States

Washington University School of Medicine

St Louis, Missouri 63110, United States

Siteman Cancer Center - South County

St Louis, Missouri 63129, United States

Memorial Sloan Kettering: Basking Ridge

Basking Ridge, New Jersey 07920, United States

Memorial Sloan Kettering: Commack

Commack, New York 11725, United States

Memorial Sloan Kettering Cancer Center

New York, New York 10065, United States

Memorial Sloan Kettering: Rockefeller Outpatient Pavilion

New York, New York 10065, United States

Gabrail Cancer Center Research

Canton, Ohio 44718, United States

Cleveland Clinic Taussig Cancer Institute

Cleveland, Ohio 44195, United States

Casey Eye Institute-South Waterfront

Portland, Oregon 97239, United States

OHSU Center for Health and Healing

Portland, Oregon 97239, United States

OHSU Research Pharmacy Services

Portland, Oregon 97239, United States

Oregon Health and Science University

Portland, Oregon 97239, United States

Henry-Joyce Cancer Clinic

Nashville, Tennessee 37232, United States

Vanderbilt Eye Institute

Nashville, Tennessee 37232, United States

The University of Texas MD Anderson Cancer Center

Houston, Texas 77030-4009, United States

Scott & White Clinic - Temple Pavilion

Temple, Texas 76504, United States

Scott & White Medical Center - Temple

Temple, Texas 76508, United States

Spokane Eye Clinic

Spokane, Washington 99204, United States

Inland Imaging, LLC Holy Family Hospital

Spokane, Washington 99208, United States

Medical Oncology Associates, PS DBA Summit Cancer Centers

Spokane, Washington 99208, United States

Providence Holy Family Nuclear Medicine

Spokane, Washington 99208, United States

Medical Oncology Associates, PS DBA Summit Cancer Centers

Spokane Valley, Washington 99216, United States

University of Wisconsin Clinical Science Center

Madison, Wisconsin 53792, United States

CLINICA PERGAMINO S.A. (Centro de Investigacion Pergamino S.A.)

Pergamino, Buenos Aires 2700, Argentina

Centro Medico INFINITO

Santa Rosa, La Pampa Province L6300EAN, Argentina

Centro Medico CAIPO (Centro para la Atención del paciente Oncológico)

San Miguel de Tucumán, Tucumán Province T4000GTB, Argentina

Clinica Universitaria Reina Fabiola

Córdoba, X5004FHP, Argentina

Centro Oncologico Riojano Integral - CORI

La Rioja, 5300, Argentina

St Vincent's Clinic

Darlinghurst, NEW South Wales (nsw) 2010, Australia

St Vincent's Hospital Sydney

Darlinghurst, NEW South Wales (nsw) 2010, Australia

Marsden Eye Specialists

Parramatta, NEW South Wales (nsw) 2150, Australia

Newcastle Eye Centre

Sydney, NEW South Wales (nsw) 2300, Australia

Mater Misericordiae Limited

South Brisbane, Queensland 4101, Australia

Central Adelaide Local Health Network Inc. operating as Royal Adelaide Hospital

Adelaide, South Australia 5000, Australia

Flinders Medical Centre

Bedford Park, South Australia 5042, Australia

Central Adelaide Local Health Network Inc. operating as The Queen Elizabeth Hospital

Woodville South, South Australia 5011, Australia

Monash Health Translation Precinct - Monash Health

Clayton, Victoria 3168, Australia

Austin Health

Heidelberg, Victoria 3084, Australia

Peter MacCallum Cancer Centre

Melbourne, Victoria 3000, Australia

Klinikum Wels - Grieskirchen GmbH, Abteilung fuer Innere Medizin IV

Wels, Upper Austria 4600, Austria

Klinikum Wels-Grieskirchen GmbH, Abteilung fuer Augenheilkunde und Optometrie

Wels, Upper Austria 4600, Austria

Klinikum Wels-Grieskirchen GmbH, Abteilung fuer Innere Medizin II

Wels, Upper Austria 4600, Austria

Klinikum Wels-Grieskirchen GmbH, Institut fuer Nuklearmedizin

Wels, Upper Austria 4600, Austria

Klinikum Wels-Grieskirchen GmbH, Institut fuer Radiologie I

Wels, Upper Austria 4600, Austria

DZU, Diagnose Zentrum Urania GmbH

Vienna, 1010, Austria

AKH Wien

Vienna, 1090, Austria

Medizinische Universitaet Wien/AKH Wien

Vienna, 1090, Austria

Medizinische Universität Wien/AKH Wien

Vienna, 1090, Austria

Centre Hospitalier de l'Ardenne - Site de Libramont

Libramont-Chevigny, Luxembourg 6800, Belgium

AZ Sint-Jan Brugge - Oostende AV - Campus Sint-Jan - Oncology

Bruges, WEST Vlaanderen 8000, Belgium

Imelda Ziekenhuis

Bonheiden, 2820, Belgium

Grand Hopital de Charleroi (GHdC)

Charleroi, 6000, Belgium

UZ Antwerpen

Edegem, 2650, Belgium

AZ Maria Middelares

Ghent, 9000, Belgium

University Hospital Gasthuisberg (UZ Leuven)

Leuven, 3000, Belgium

Centre Hospitalier Universitaire (CHU) de Liege

Liège, 4000, Belgium

CHC Saint Joseph

Liège, 4000, Belgium

AZ Delta Roeselaere-Menen

Roeselaere, 8800, Belgium

Centre Hospitalier Regional (CHR) - Verviers

Verviers, 4800, Belgium

CEMES Centro Medico Especializado em Oftalmologia

Cachoeiro de Itapemirim, Espírito Santo 29300-045, Brazil

Centro de Pesquisas Clínicas em Oncologia

Cachoeiro de Itapemirim, Espírito Santo 29308-014, Brazil

Hospital Evangelico de Cachoeiro de Itapemirim

Cachoeiro de Itapemirim, Espírito Santo 29308-055, Brazil

Hospital do Olho

Salvador, Estado de Bahia 41820-020, Brazil

CENOB - Centro de Oncologia da Bahia SS Ltda / Oncovida

Salvador, Estado de Bahia 41820-021, Brazil

Instituto Vizibelli

Belo Horizonte, Minas Gerais 30110-921, Brazil

CENANTRON - Centro Avancado de Tratamento Oncologic

Belo Horizonte, Minas Gerais 30130-090, Brazil

Fundação Universidade de Caxias do Sul

Caxias do Sul, Rio Grande do Sul 95070-560, Brazil

Daniel Lubisco Pandolfi

Lajeado, Rio Grande do Sul 95900-000, Brazil

Sociedade Beneficencia e Cardade de Lajeado/Hospital Bruno Born

Lajeado, Rio Grande do Sul 95900-000, Brazil

Sociedade Beneficencia e Cardade de Lajeado/Hospital Bruno Born

Lajeado, Rio Grande do Sul 95900-010, Brazil

Associacao Hospitalar Beneficente Sao Vicente de Paulo / Hospital Sao Vicente de Paulo

Passo Fundo, Rio Grande do Sul 99010-080, Brazil

Consultorio Medico de Oftalmologia - Dr. Ricardo Tres

Passo Fundo, Rio Grande do Sul 99010-080, Brazil

Hospital Sao Vicente de Paulo

Passo Fundo, Rio Grande do Sul 99010-090, Brazil

Thiago Vernetti Ferreira

Pelotas, Rio Grande do Sul 96010-140, Brazil

Leandro Becker

Pelotas, Rio Grande do Sul 96015-280, Brazil

Fernanda Mendes

Pelotas, Rio Grande do Sul 96020-080, Brazil

UPCO - Unidade de Pesquisas Clinicas em Oncologia

Pelotas, Rio Grande do Sul 96020-080, Brazil

Fernanda Lauermann

Pelotas, Rio Grande do Sul 96020-260, Brazil

Diogo Duarte Torre

Porto Alegre, Rio Grande do Sul 90020-013, Brazil

Farmacia Central da Irmandade da Santa Casa de Misericordia de Porto Alegre

Porto Alegre, Rio Grande do Sul 90020-090, Brazil

Irmandade da Santa Casa de Misericordia de Porto Alegre

Porto Alegre, Rio Grande do Sul 90020-090, Brazil

Nucleo de Novos Tratamentos em Cancer

Porto Alegre, Rio Grande do Sul 90050-170, Brazil

Centro de Pesquisa Clínica de Oncologia e Hematologia - Hospital Mãe de Deus/AESC

Porto Alegre, Rio Grande do Sul 90110-270, Brazil

Clinica de Oftalmologia Lavinsky

Porto Alegre, Rio Grande do Sul 90470-340, Brazil

Hospital Mãe de Deus

Porto Alegre, Rio Grande do Sul 90880-480, Brazil

Giuliano Santos Borges - ME / Clinica de Neoplasias Litoral - Centro de Novos Tratamentos Itajai

Itajaí, Santa Catarina 88301-220, Brazil

Clinica Toller

Barretos, São Paulo 14780-110, Brazil

Olhos Centro Diagnostico e Laser LTDA

Barretos, São Paulo 14780-300, Brazil

Fundacao Pio XII

Barretos, São Paulo 14784-400, Brazil

FUNDAÇÃO DO ABC - Faculdade de Medicina do ABC

Santo André, São Paulo 09060-650, Brazil

FUNDAÇÃO DO ABC - Faculdade de Medicina do ABC

Santo André, São Paulo 09060-870, Brazil

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto

São José do Rio Preto, São Paulo 15090-000, Brazil

CEPOS - Centro de Estudos e Pesquisas Oncologicas de Sorocaba

Sorocaba, São Paulo 18030-075, Brazil

Instituto de Oncologia de Sorocaba "Dr. Gilson Delgado"

Sorocaba, São Paulo 18030-200, Brazil

Karen Miyuki Kubokawa Shorer

Sorocaba, São Paulo 18040-425, Brazil

Oftalmologia Diagnostica de Sorocaba (ODS)

Sorocaba, São Paulo 18047-620, Brazil

Instituto de Ensino e Pesquisa São Lucas

São Paulo, 01236-030, Brazil

Instituto de Ensino e Pesquisa São Lucas - Pharmacy

São Paulo, 01242-020, Brazil

Hospital Leforte

São Paulo, 01507-000, Brazil

IPEPO - Instituto da Visao

São Paulo, 04038-020, Brazil

Eye Care Centre, Vancouver General Hospital

Vancouver, British Columbia V5Z 3N9, Canada

BC Cancer, Vancouver Center

Vancouver, British Columbia V5Z 4E6, Canada

The Ottawa Hospital Cancer Centre

Ottawa, Ontario K1H 8L6, Canada

Sunnybrook Research Institute

Toronto, Ontario M4N 3M5, Canada

Mount Sinai Hospital

Toronto, Ontario M5G 1X5, Canada

Centre integre universitaire de sante et de services sociaux de l'Ouest-de-l'Ile-de-Montreal

Montreal, Quebec H3T 1M5, Canada

Instituto Clinico Oncologico del Sur (ICOS)

Temuco, Araucania 4810469, Chile

Hospital Clinico Vina Del Mar

Viña del Mar, V Region Valparaiso 2520612, Chile

Ocni ordinace Oftalpro s.r.o.

Brno, 603 00, Czechia

Masarykuv onkologicky ustav

Brno, 656 53, Czechia

Fakultni nemocnice Hradec Kralove

Hradec Králové, 500 05, Czechia

Fingerlanduv ustav patologie

Hradec Králové, 500 05, Czechia

I. interni kardioangiologicka klinika

Hradec Králové, 500 05, Czechia

Klinika nemoci koznich a pohlavnich

Hradec Králové, 500 05, Czechia

Nemocnicni lekarna - Usek klinickych studii

Hradec Králové, 500 05, Czechia

Ocni klinika

Hradec Králové, 500 05, Czechia

Radiologicka klinika

Hradec Králové, 500 05, Czechia

Fakultni nemocnice Olomouc, I. interni klinika - kardiologicka

Olomouc, 779 00, Czechia

Fakultni nemocnice Olomouc, Lekarna

Olomouc, 779 00, Czechia

Fakultni nemocnice Olomouc

Olomouc, 779 00, Czechia

Odense University Hospital (OUH)

Odense C, DK-5000, Denmark

Hopital Jean Minjoz

Besançon, 25030, France

CHU Morvan

Brest, 29609, France

Centre Ophtalmologique - Pole Vision - Clinique Val d'Ouest

Écully, 69130, France

Centre Leon Berard

Lyon, 69373, France

ICM Val d'Aurelle

Montpellier, 34298, France

CHU HOTEL-Dieu

Nantes, 44093, France

Hopital Georges Pompidou

Paris, 75015, France

Centre hospitalier national d'ophtalmologie des Quinze-Vingts

Paris, 75571, France

Centre Hospitalier National d'Opthalmologie des Quinze-Vingts (CHNO des XV-XX)

Paris, 75571, France

CHU Robert Debre

Reims, 51092, France

SCM Centre d'ophtalmologie

Saint Jeand de Vedas, 34430, France

CHU Toulouse - Purpan, hopital Pierre-Paul Riquet

Toulouse, 31057, France

CHU Toulouse-Institut Inuversitaire du Cancer Toulouse

Toulouse, 31059, France

CHU Toulouse-Rangueil

Toulouse, 31059, France

Gustave Roussy

Villejuif, 94805, France

Universitaetsklinikum Tuebingen

Tübingen, Baden-Wurttemberg 72076, Germany

Universitaetsklinikum Ulm

Ulm, Baden-Wurttemberg 89081, Germany

Augenklinik der Universitaet Muenchen

Munich, Bavaria 80336, Germany

LMU Klinikum der Universitaet Muenchen, Campus Grosshadern

Munich, Bavaria 81377, Germany

Augenarzt-Gemeinschaftspraxis Dr.med.Andreas Kind & Dr.med. Ute Kariger-Schweigert

Falkensee, Brandenburg 14612, Germany

Medizinische Hochschule Hannover (MHH)

Hanover, Lower Saxony 30625, Germany

Medizinische Hochschule Hannover

Hanover, Lower Saxony 30625, Germany

Institut f. Pathologie - Ruhr-Universitaet Bochum, Prof. Dr. med. Andrea Tannapfel

Bochum, North Rhine Westfalia 44789, Germany

Kliniken Essen Mitte / Knappschaftskrankenhaus

Essen, North Rhine-Westphalia 35136, Germany

Praxis fuer Augenheilkunde Dr. Edmund Meyer-Schwickerath

Essen, North Rhine-Westphalia 45131, Germany

Kliniken Essen-Mitte

Essen, North Rhine-Westphalia 45136, Germany

Universitaetsklinikum Essen (AoeR), Innere Klinik (Tumorforschung), Westdeutsches Tumorzentrum

Essen, North Rhine-Westphalia 45147, Germany

Universitaetsklinikum Essen; Diagnostischeu. Interventionelle Radiologie u. Neuroradiologie

Essen, North Rhine-Westphalia 45147, Germany

Universitaetsklinikum Essen; Nuklearmedizin

Essen, North Rhine-Westphalia 45147, Germany

Universitaetsklinikum Essen; Zentralapotheke

Essen, North Rhine-Westphalia 45147, Germany

Evang. Krankenhaus Essen - Werden; Klinik fuer Augenheilkunde

Essen, North Rhine-Westphalia 45239, Germany

Kliniken Essen Mitte / Knappschaftskrankenhaus

Essen, North Rhine-Westphalia 45276, Germany

Augentagesklinik Maria-Hilf Krankenhaus

Mönchengladbach, North Rhine-Westphalia 41063, Germany

Kliniken Maria Hilf GmbH - Franziskuskrankenhaus

Mönchengladbach, North Rhine-Westphalia 41063, Germany

Kliniken Maria Hilf GmbH; Klinik fuer Radiologie

Mönchengladbach, North Rhine-Westphalia 41063, Germany

Lukaskrankenhaus Neuss; Zentrale Apotheke

Neuss, North Rhine-Westphalia 41464, Germany

Augenarzt Praxis Dr. med. Petra Huelsmann

Worms, Rhineland-Palatinate 67547, Germany

Gemeinschaftspraxis fuer Radiologie und Nuklearmedizin, Standort Worms

Worms, Rhineland-Palatinate 67547, Germany

Martin Apotheke

Worms, Rhineland-Palatinate 67547, Germany

Onkologische Schwerpunktpraxis Worms

Worms, Rhineland-Palatinate 67547, Germany

Praxisgemeinschaft Kruse + Hofstaetter

Worms, Rhineland-Palatinate 67547, Germany

Evangelisches Waldkrankenhaus Spandau

Berlin, 13589, Germany

Universitaetsklinikum Carl Gustav Carus der Technischen Universitaet Dresden

Dresden, 01307, Germany

Universitaetsklinikum Hamburg Eppendorf, Klinik fuer Augenheilkunde

Hamburg, 20246, Germany

Facharztzentrum Eppendorf

Hamburg, 20249, Germany

Universitaetsklinikum Hamburg Eppendorf, Zentrum fuer Radiologie und Endoskopie

Hamburg, 20251, Germany

ZytoService Deutschland GmbH, Standort-Hamburg-Jenfeld

Hamburg, 22045, Germany

HKS Kardiologische Praxis am Israelitischen Krankenhaus

Hamburg, 22297, Germany

Radiologie im Israelitischen Krankenhaus

Hamburg, 22297, Germany

Zala Megyei Szent Rafael Korhaz - Onkologiai Osztaly

Zalaegerszeg, Zala County H-8900, Hungary

Szent Margit Kórház

Budapest, 1032, Hungary

Eszak-Pesti Centrumkorhaz-Honvedkorhaz

Budapest, 1062, Hungary

Magyar Honvedseg Egeszsegugyi Kozpont

Budapest, 1062, Hungary

Egyesitett Szent Istvan es Szent Laszlo Korhaz-Rendelointezet

Budapest, 1097, Hungary

Uzsoki Utcai Korhaz

Budapest, 1145, Hungary

Debreceni Egyetem Klinikai Kozpont

Debrecen, 4032, Hungary

Pecsi Tudomanyegyetem Altalanos Orvostudomanyi Kar

Pécs, 7624, Hungary

Pecsi Tudomanyegyetem Klinikai Kozpont

Pécs, 7624, Hungary

Tel Aviv Sourasky Medical Center - Oncology

Tel Aviv, NAP 6423906, Israel

The Barzilai Medical Center - Oncology Institute

Ashkelon, 7830604, Israel

Soroka University Medical Center

Beersheba, 8410101, Israel

MOR Institute

Bnei Brak, 5126413, Israel

Ein-Karem Department of Medical Imaging of Hadassah Medical Organization, Hadassah Medical Center,

Jerusalem, 9112001, Israel

Hadassah Medical Organization, Hadassah Medical Center, Ein-Karem

Jerusalem, 9112001, Israel

Pharmacy of Hadassah Medical Organization, Hadassah Medical Center, Ein-Karem

Jerusalem, 9112001, Israel

Mt. Scopus Department of Medical Imaging of Hadassah Medical Organization,

Jerusalem, 91240, Israel

Imaging Department of Meir Medical Center

Kfar Saba, 4428164, Israel

Meir Medical Center

Kfar Saba, 4428164, Israel

Pharmacy of Rabin Medical Center, Beilinson Hospital

Petah Tikva, 4941492, Israel

Rabin Medical Center, Beilinson Hospital

Petah Tikva, 4941492, Israel

The Chaim Sheba Medical Center

Tel Litwinsky, 5262100, Israel

Ospedali Riuniti Umberto I

Torrette Di Ancona, Ancona 60020, Italy

ASST Bergamo Ovest, Ospedale Treviglio Caravaggio di Trevigl

Treviglio, Bergamo 24047, Italy

Oculistica, ASST Papa Giovanni XXIII

Bergamo, BG 24127, Italy

Oncologia, ASST Papa Giovanni XXIII

Bergamo, BG 24127, Italy

Clinica di Oncologia Medica AOU di Cagliari Presidio Duilio Casula Monserrato

Monserrato, Cagliari 09042, Italy

Farmacia AOU di Cagliari Presidio Duilio Casula Monserrato

Monserrato, Cagliari 09042, Italy

Radiologia AOU di Cagliari Presidio Duilio Casula Monserrato

Monserrato, Cagliari 09042, Italy

Oculistica - ASST Cremona, Ospedale di Cremona

Cremona, CR 26100, Italy

SC Farmacia Aziendale - ASST Cremona, Ospedale di Cremona

Cremona, CR 26100, Italy

SC Oncologia - ASST Cremona, Ospedale di Cremona

Cremona, CR 26100, Italy

U.O. Oculistica, Istituto Clinico HUMANITAS

Rozzano, Milano 20089, Italy

U.O. di Oncologia ed Ematologia, Istituto Clinico HUMANITAS

Rozzano (MI), Milan 20089, Italy

IRCCS Ospedale San Raffaele - U.O. di Medicina Oncologica

Milan, MI 20132, Italy

Servizio di Farmacia - IRCCS Ospedale San Raffaele

Milan, MI 20132, Italy

S.C. Radiologia diagnostica e interventistica - Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, MI 20133, Italy

SC Oncologia Medica 1, SS Oncologia Medica Gastroenterologica

Milan, MI 20133, Italy

Cardiologia per i pazienti oncologici - Istituto Oncologico Veneto I.R.C.C.S

Padova, PD 35128, Italy

Clinica Oculistica - Azienda Ospedaliera di Padova

Padova, PD 35128, Italy

U.O. Oncologia Medica 1 - Istituto Oncologico Veneto I.R.C.C.S

Padova, PD 35128, Italy

Policlinico S.Orsola Malpighi, AOU di Bologna - Oncologia Medica

Bologna, 40138, Italy

Divisione Anatomia Patologica Presidio San Giovanni di Dio

Cagliari, 09124, Italy

Oculistica AOU di Cagliari Presidio San Giovanni di Dio

Cagliari, 09124, Italy

Dipartimento Neuromuscoloscheletrico e Organi di Senso, "Oncologia Oculare Unit"

Florence, 50134, Italy

SC oncologia Medica I - Azienda Ospedaliero Universitaria Careggi

Florence, 50134, Italy

Radiologia

Milan, 20141, Italy

Unita di Oncologia Medica Gastrointestinale e Tumori Neuroendocrini

Milan, 20141, Italy

Grande Ospedale Metropolitano Niguarda

Milan, 20162, Italy

Dipartimento Interaziendale Farmaceutico - AOU Policlinico di Modena

Modena, 41124, Italy

SC di Oftalmologia - AOU Policlinico di Modena

Modena, 41124, Italy

SC di Radiologia, Dipartimento Interaziendale integrato Diagnostica per Immagini

Modena, 41124, Italy

SSD Day Hospital Oncologico - Dipartimento ad attivita integrata di Oncologia, Ematologia

Modena, 41124, Italy

AOU Universita degli Studi della Campania L. Vanvitelli - DAI di Medicina Interna e Specialistica

Naples, 80131, Italy

AOU Universita degli Studi della Campania L. Vanvitelli - U. Ma.Ca.

Naples, 80131, Italy

AOU Universita degli Studi della Campania L. Vanvitelli

Naples, 80131, Italy

AOU Universita degli Studi della Campania L. Vanvitelli

Naples, 80138, Italy

UO Oculistica - AOU Pisana, Stabilimento Ospedaliero di Cisanello

Pisa, 56124, Italy

SOD Radiodiagnostica 3 - AOU Pisana, Stabilimento Ospedaliero di Santa Chiara

Pisa, 56126, Italy

UO Farmaceutica, Gestione del Farmaco - AOU Pisana, Stabilimento Ospedaliero di Santa Chiara

Pisa, 56126, Italy

UO Oncologia Medica 2 - AOU Pisana, Stabilimento Ospedaliero di Santa Chiara

Pisa, 56126, Italy

U.O.S.D. Oncologia Medica, Dipartimento di Medicina - Fondazione PTV Policlinico Tor Vergata

Roma, 00133, Italy

U.O.S.D. Patologie Retiniche - Fondazione PTV Policlinico Tor Vergata

Roma, 00133, Italy

Chayagasaka Eye Clinic

Nagoya, Aichi-ken 464-0092, Japan

Aichi Cancer Center Hospital

Nagoya, Aichi-ken 464-8681, Japan

National Cancer Center Hospital East

Kashiwa-shi, Chiba 277-8577, Japan

Hokkaido University Hospital

Sapporo, Hokkaido 060-8648, Japan

Kanazawa University Hospital

Kanazawa, Ishikawa-ken 920-8641, Japan

St. Marianna University School of Medicine Hospital

Kawasaki, Kanagawa 216-8511, Japan

Tsukahara Eye Clinic

Yokohama, Kanagawa 241-0821, Japan

Kanagawa Cancer Center

Yokohama, Kanagawa 241-8515, Japan

Osaka University Hospital Laboratory for Clinical Investigation

Suita, Osaka 565-0871, Japan

National Cancer Center Hospital

Chuo-ku, Tokyo 104-0045, Japan

National Hospital Organization Kyushu Cancer Center

Fukuoka, 811-1395, Japan

Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers

Fukuoka, 815-8588, Japan

National Hospital Organization Osaka National Hospital

Osaka, 540-0006, Japan

Consultorio dentro de la Torre Medica Dalinde (Oncologia Medica)

Mexico City, Cuauhtemoc 06760, Mexico

Superare Centro de Infusion S.A. de C.V.

Delegacion Cuauhtemoc, Mexico City 06760, Mexico

Rijnstate Hospital Arnhem

Arnhem, Gelderland 6815 AD, Netherlands

Rijnstate Hospital Velp

Velp, Gelderland 6883 AZ, Netherlands

Maastricht University Medical Center (MUMC)

Maastricht, Limburg 6229HX, Netherlands

The Netherlands Cancer Institute

Amsterdam, North Holland 1066 CX, Netherlands

Onze Lieve Vrouwen Gasthuis

Amsterdam, North Holland 1091 AC, Netherlands

Haga Ziekenhuis

The Hague, South Holland 2545 AA, Netherlands

Universitair Medisch Centrum Utrecht

Utrecht, 3584 CX, Netherlands

Universitair Medisch Centrum Utrecht

Utrecht, 3584CX, Netherlands

Colosseum Øyelegesenter C/O LB Holdings AS

Lommedalen, 1350, Norway

Colosseum Øyelegesenter C/O LB Holdings AS

Oslo, 0369, Norway

Oslo universitetssykehus, Radiumhospitalet

Oslo, 0379, Norway

Sykehusapoteket Oslo, Radiumhospitalet

Oslo, 0379, Norway

Szpital Specjalistyczny W Brzozowie, Podkarpacki Osrodek Onkologiczny Im.Ks.B.Markiewicza

Brzozów, 36-200, Poland

Wojewodzki Szpital Zespolony, Oddzial Onkologiczny

Elblag, 82-300, Poland

Szpital Specjalistyczny im. L. Rydygiera w Krakowie Sp.z.o.o.

Krakow, 31-826, Poland

Europejskie Centrum Zdrowia Otwock, Szpital im. F. Chopina

Otwock, 05-400, Poland

NZOZ Centrum Medyczne HCP

Poznan, 61-485, Poland

NZOZ Przychodnia Specjalistyczna GUTMED

Poznan, 61495, Poland

MAGODENT Sp. z o.o. Szpital Elblaska

Warsaw, 01-748, Poland

Regional Budgetary Healthcare Institution Kursk Regional Clinical

Kursk, Kursk Oblast 305524, Russia

Evimed Llc

Chelyabinsk, 454048, Russia

Federal State Budget Institution "N.N. Blokhin Russian Cancer Research Center" of the

Moscow, 115478, Russia

Federal State Budget Institution "N.N. Blokhin Russian Cancer Research Center"

Moscow, 115478, Russia

A. Tsyb Medical Radiological Research Center - branch of the

Obninsk, 249036, Russia

State Budgetary Educational Institution of Higher Professional Education First Saint Petersburg

Saint Petersburg, 197022, Russia

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do 13620, South Korea

Ajou University Hospital

Suwon, Gyeonggi-do 16499, South Korea

Hallym University Sacred Heart Hospital

Anyang, Gyeonggido 14068, South Korea

Chonnam National University Hwasun Hospital

Hwasun-gun, Jeollanam-do 58128, South Korea

Korea University Guro Hospital

Seoul, Seoul Teugbyeolsi 08308, South Korea

Dong-A University Hospital

Busan, 49201, South Korea

Gachon University Gil Medical Center

Incheon, 21565, South Korea

Korea University Anam Hospital IRB

Seoul, 02841, South Korea

Seoul National University Hospital

Seoul, 03080, South Korea

Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea

Asan Medical Center

Seoul, 05505, South Korea

Samsung Medical Center

Seoul, 06351, South Korea

The Catholic University of Korea, Seoul St. Mary's Hospital

Seoul, 06591, South Korea

Complejo Hospitalario de Jaen

Jaén, Andalusia 23007, Spain

Sercosa - Clinica de las Nieves

Jaén, Andalusia 23007, Spain

Hospital Universitario Son Espases

Palma de Mallorca, Balearic Islands 07010, Spain

Institut Catala d'Oncologia

L'Hospitalet de Llobregat, Barcelona 08908, Spain

Hospital Universitari Parc Tauli

Sabadell, Barcelona 08208, Spain

Hospital Universitario Reina Sofía

Córdoba, Cordona 14004, Spain

Hospital Nuestra Señora del Rosario

Madrid, Madrid, Communidad Delaware 28006, Spain

Hospital Universitari Sant Joan de Reus

Reus, Tarragona 43204, Spain

Hospital del Mar

Barcelona, 08003, Spain

Clinica Corachan

Barcelona, 08017, Spain

Hospital Quiron Salud Barcelona

Barcelona, 08023, Spain

Cetir Centre Medic S.L.

Barcelona, 08029, Spain

Hospital Universitario Vall d'Hebron

Barcelona, 08035, Spain

Hospital Universitario de Burgos

Burgos, 09006, Spain

Consulta Dr. Juan Carlos Castillo Dominguez

Córdoba, 14008, Spain

Gabinete Radiologico Dr. Pita

Madrid, 28006, Spain

Hospital General Universitario Gregorio Maranon

Madrid, 28007, Spain

Hospital Universitario Ramón y Cajal

Madrid, 28034, Spain

Hospital Clinico San Carlos

Madrid, 28040, Spain

Hospital Universitario Fundacion Jimenez Diaz

Madrid, 28040, Spain

Hospital Universitario 12 de Octubre

Madrid, 28041, Spain

Hospital Universitario La Paz

Madrid, 28046, Spain

Hospital HM Universitario Sanchinarro

Madrid, 28050, Spain

Hospital Universitario Virgen del Rocio

Seville, 41013, Spain

Clinica Oftalvist

Valencia, 46004, Spain

Fundacion Instituto Valenciano de Oncologia

Valencia, 46009, Spain

Hospital Clinico Universitario de Valencia

Valencia, 46010, Spain

Hospital General Universitario de Valencia

Valencia, 46014, Spain

Hospital Quiron Salud Zaragoza

Zaragoza, 50006, Spain

Hospital Universitario Miguel Servet

Zaragoza, 50009, Spain

Changhua Christian Hospital

Changhua, Changhua County 500, Taiwan

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, 807, Taiwan

China Medical University Hospital

Taichung, 40447, Taiwan

National Cheng Kung University Hospital

Tainan, 704, Taiwan

National Taiwan University Hospital

Taipei, 10002, Taiwan

Chang Gung Memorial Hospital, Linkou

Taoyuan City, 333, Taiwan

Ege University Medical Faculty

Izmir, Bornova 35040, Turkey (Türkiye)

Izmir Medical Park Hospital - Medical Oncology

Izmir, Izmir, Karsiyaka 35575, Turkey (Türkiye)

Medeniyet University Goztepe Training and Research Hospital

Istanbul, Kadikoy 34722, Turkey (Türkiye)

Hacettepe University Medical Faculty

Ankara, 06230, Turkey (Türkiye)

Uludag University Hospital

Bursa, 16059, Turkey (Türkiye)

Trakya Universitesi Tip Fakultesi

Edirne, 22030, Turkey (Türkiye)

Inonu Universitesi Turgut Ozal Medical Center

Malatya, 44280, Turkey (Türkiye)

Oftalmolohycheskyi tsentr "Vzghliad" MTs

Dnipropetrovsk, Dnipropetrovsk Oblast 41100, Ukraine

Oftalmolohycheskyi tsentr "Vzghliad" MTs

Dnipropetrovsk, Dnipropetrovsk Oblast 49027, Ukraine

Derzhavnyi zaklad, Dnipropetrovska medychna akademiia Ministerstva okhorony zdorovia Ukrainy

Dnipropetrovsk, Dnipropetrovsk Oblast 49102, Ukraine

Komumalnyi zaklad, Dnipropetrovska miska bahatoprofilna klinichna likarnia Nº4

Dnipropetrovsk, Dnipropetrovsk Oblast 49102, Ukraine

Kyivska klinichna likarnia na zaliznychnomu transporti No3 filii Tsentr okhorony zdorov'ia PAT

Kyiv, Kyivska Oblast' 02096, Ukraine

Natsionalnyi medychnyi universytet imeni O.O Bohomltsia, kafedra onkolohii

Kyiv, Kyivska Oblast' 02096, Ukraine

Natsionalnyi medychnyi universytet imeni O.O Bohomltsia, kafedra oftalmolohii

Kyiv, Kyivska Oblast 01601, Ukraine

Oleksandrivska klinichna likarnia mista Kyieva

Kyiv, Kyivska Oblast 01601, Ukraine

Kyivskyi miskyi klinichnyi onkotsentr

Kyiv, Kyivska Oblast 03115, Ukraine

Vinnytskyi oblasnyi klinichnyi onkolohichnyi dyspanser, viddilennia khimioterapii

Vinnytsia, Vinnytsia Oblast 21029, Ukraine

DVNZ "Uzhhorodskyi natsionalnyi universytet"

Uzhhorod, Zakarpattia Oblast 88000, Ukraine

TOV "Zakarpatskyi Tsentr Mikrokhirurhii Oka"

Uzhhorod, Zakarpattia Oblast 88000, Ukraine

Tsentralna miska klinichna likarnia, Miskyi onkolohichnyi tsentr

Uzhhorod, Zakarpattia Oblast 88000, Ukraine

NHS Grampian - Aberdeen Royal Infirmary

Aberdeen, Aberdeenshire Scotland AB25 2ZN, United Kingdom

King Edward V11 Hospital

Windsor, Berkshire SL4 3DP, United Kingdom

Beatson West of Scotland Cancer Centre

Glasglow, Glasglow City, Scotland G12 0YH, United Kingdom

University Hospitals Birmingham NHS Foundation Trust Queen Elizabeth Hospital

Birmingham, WEST Midlands B15 2TH, United Kingdom

Hammersmith Hospital, Imperial College Healthcare NHS Trust

London, W12 0HS, United Kingdom

Imperial College Healthcare NHS Trust, Hammersmith Hospital

London, W12 0HS, United Kingdom

Sarah Cannon Research Institute UK

London, W1G 6AD, United Kingdom

Imperial College Healthcare NHS Trust, Charing Cross Hospital

London, W6 8RF, United Kingdom

The Christie NHS Foundation Trust - Christie Hospital

Manchester, M20 4BX, United Kingdom