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| ID | Type | Description | Link |
|---|---|---|---|
| A530900 | Other Identifier | UW Madison | |
| SMPH/ANESTHESIOLOGY/ANESTHESIO | Other Identifier | UW Madison | |
| Protocol Version 4/20/2020 | Other Identifier | UW Madison |
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The IPOD-B2 Study aims to understand the pathogenesis of postoperative delirium in patients undergoing major surgery. The investigators will identify then correlate soluble biomarkers in blood and cerebral spinal fluid with changes in High Density-Electroencephalogram.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High Density-Electroencephalogram | Procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline and correlation between biomarker levels in CSF and HD-EEG changes | Pre-operative measure: Up to 4 weeks prior to surgery. Post-operative measure: Up to postoperative day (POD) 9 |
| Measure | Description | Time Frame |
|---|---|---|
| Absolute changes in biomarkers in CSF and plasma in delirious and non-delirious patients between baseline and post-operative period | Pre-operative measure: Up to 4 weeks prior to surgery. Post-operative measure: Up to postoperative day (POD) 9 | |
| Correlation between biomarkers in CSF and plasma in delirious and non-delirious patients |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing elective open thoracoabdominal aortic aneurysm or thoracic endovascular aortic/aneurysm repair surgery.
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| Name | Affiliation | Role |
|---|---|---|
| Richard Lennertz, MD PhD | University of Wisconsin-Madison, School of Medicine and Public Health | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Wisconsin-Madison | Madison | Wisconsin | 53705 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42011187 | Derived | Wu JG, Taylor J, Kunkel D, Maze M, Pearce RA, Sanders RD, Lennertz R. The association between cerebrospinal fluid interleukin-6, soluble interleukin-6 receptor, and interleukin-6 trans-signalling binary complex with postoperative delirium: an observational cohort study. BJA Open. 2026 Apr 10;18:100546. doi: 10.1016/j.bjao.2026.100546. eCollection 2026 Jun. | |
| 35144802 |
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| ID | Term |
|---|---|
| D003693 | Delirium |
| ID | Term |
|---|---|
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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Participant blood and cerebral spinal fluid samples will be collected and stored for future analysis.
| Post-operative measure: Up to postoperative day (POD) 9 |
| Absolute changes in activity and connectivity in HD-EEG from baseline to postoperative | Pre-operative measure: Up to 4 weeks prior to surgery. Post-operative measure: Up to postoperative day (POD) 9 |
| Correlation of biomarkers with the incidence of spinal cord ischemia | Pre-operative measure: Up to 4 weeks prior to surgery. Post-operative measure: Up to postoperative day (POD) 9 |
| Taylor J, Parker M, Casey CP, Tanabe S, Kunkel D, Rivera C, Zetterberg H, Blennow K, Pearce RA, Lennertz RC, Sanders RD. Postoperative delirium and changes in the blood-brain barrier, neuroinflammation, and cerebrospinal fluid lactate: a prospective cohort study. Br J Anaesth. 2022 Aug;129(2):219-230. doi: 10.1016/j.bja.2022.01.005. Epub 2022 Feb 8. |
| 34958346 | Derived | Tanabe S, Parker M, Lennertz R, Pearce RA, Banks MI, Sanders RD. Reduced Electroencephalogram Complexity in Postoperative Delirium. J Gerontol A Biol Sci Med Sci. 2022 Mar 3;77(3):502-506. doi: 10.1093/gerona/glab352. |
| 34260706 | Derived | Parker M, White M, Casey C, Kunkel D, Bo A, Blennow K, Zetterberg H, Pearce RA, Lennertz R, Sanders RD. Cohort Analysis of the Association of Delirium Severity With Cerebrospinal Fluid Amyloid-Tau-Neurodegeneration Pathologies. J Gerontol A Biol Sci Med Sci. 2022 Mar 3;77(3):494-501. doi: 10.1093/gerona/glab203. |
| 33228978 | Derived | Ballweg T, White M, Parker M, Casey C, Bo A, Farahbakhsh Z, Kayser A, Blair A, Lindroth H, Pearce RA, Blennow K, Zetterberg H, Lennertz R, Sanders RD. Association between plasma tau and postoperative delirium incidence and severity: a prospective observational study. Br J Anaesth. 2021 Feb;126(2):458-466. doi: 10.1016/j.bja.2020.08.061. Epub 2020 Nov 20. |
| 32499013 | Derived | Tanabe S, Mohanty R, Lindroth H, Casey C, Ballweg T, Farahbakhsh Z, Krause B, Prabhakaran V, Banks MI, Sanders RD. Cohort study into the neural correlates of postoperative delirium: the role of connectivity and slow-wave activity. Br J Anaesth. 2020 Jul;125(1):55-66. doi: 10.1016/j.bja.2020.02.027. Epub 2020 Jun 1. |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |