Continuous Glucose Monitoring During Diets That Differ in Glycemic Load

Continuous Glucose Monitoring During Diets That Differ in Glycemic Load

This study test whether a Continuous Glucose Monitor can pickup differences in glucose (in the interstitial fluid) during a dietary intervention using meals with either a high with a low glycemic load.

The aim of this study is to determine the suitability of a continuous glucose monitor to detect the impact of a dietary intervention on postprandial blood glucose levels in normal, healthy, free living subjects. We will compare a dietary intervention of meals with a high glycemic load (high post-meal blood glucose) versus meals with a low glycemic load (low post-meal blood glucose) in a cross-over study. In addition, the glucose profiles obtained both via venous blood sampling and via continuous glucose monitor following a standard carbohydrate load will be compared.

Inclusion Criteria:

• Apparently healthy males and post-menopausal females
• Age at start of the study ≥ 50 and ≤ 70 years
• Body mass index (BMI) ≥ 25.0 and ≤ 35.0 kg/m2
• Fasting blood glucose value of subjects is ≥ 3.4 and < 6.1 mmol/L at screening
• Being used to eat three meals a day
• Having a general practitioner
• Agreeing to be informed about medically relevant personal test-results by a physician
• Accessible veins on arms as determined by examination at screening.

Exclusion Criteria:

• Having a medical conditions which might affect the study measurements (including but not limited to: diabetes type 1 and type 2, gastrointestinal disorders, gastrointestinal surgery and inflammatory diseases, as judged by the study physician
• Reported use of over-the-counter or prescribed medication or food supplements, which may interfere with study measurements as judged by the principal investigator
• Use of oral antibiotics in 40 days or less prior to the start of the study
• Reported participation in another nutritional or biomedical study 3 months before the screening or during the study
• Reported participation in night shift work 2 weeks prior to screening or during the study. Night work is defined as working between mid-night and 6.00 am
• Reported intense sporting activities > 2h/w. Intense sporting activities are defined as those activities that cause a lack of breath which limits the ability to have a normal conversation
• Reported alcohol consumption > 10 units/week (female) or > 14 units/week (male)
• Reported use of any nicotine containing products in the 6 months preceding the study and willing to abstain from use of nicotine containing products during the study itself
• Reported dietary habits: medically prescribed diet, slimming diet, vegetarian
• Reported weight loss/gain (> 3 kg) in the last 2 months before the study
• Being an employee of Unilever or research departments in NUTRIM or the Maastricht University Medical Centre (MUMC+) collaborating in this study
• Known allergy or intolerance to food products.
• Blood donation in the past 3 months