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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Moxibustion group | Experimental | drug:moxa Moxibustion was to stimulate acupoints of Guanyuan(RN4)and the Zusanli(ST36) with burned moxa. |
|
| Acupuncture group | Experimental | material: stainless steel needle In acupuncture treatment, needles were applied to acupoints of Guanyuan(RN4)and Zusanli(ST36),with manipulations to get Deqi sensation. |
|
| Placebo group | Placebo Comparator | material: stainless steel needle Needles were applied to acupoints of Guanyuan(RN4)and Zusanli(ST36),but without any manipulations and Deqi sensation. |
|
| Zusanli（ST36)-acupuncture group | Experimental | material: stainless steel needle Stimulating acupoints of Zusanli(ST36) with acupuncture. |
|
| Guanyuan(RN4)-acupuncture group | Experimental | material: stainless steel needle. Stimulating acupoint of Guanyuan(RN4) with acupuncture. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acupuncture | Other | Stimulating acupoints by using stainless steel needles with manual manipulation. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Chalder's Fatigue Scale Score(CFSS) | In CFSS, symptoms of fatigue are assessed by scores ranging from 0 to 3. | Two years |
| Measure | Description | Time Frame |
|---|---|---|
| Numeric Rating Scale(NRS) | NRC is a 10cm scale to assess the fatigue degree ranging from 0 to 10, the score of 0 stands for 'no fatigue' and 10 for 'serious'. | Two years |
| 36-item Short-Form Health Survey (SF-36) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Liang feng xia, Doctor | Contact | +86 18971371818 | 315938821@qq.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hubei university of TCM | Wuhan | Hubei | 430000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40315935 | Derived | Li T, Litscher G, Zhou Y, Song Y, Shu Q, Chen L, Huang Q, Wang Y, Tian H, Teng R, Wang H, Liang F. Effects of acupuncture and moxibustion on heart rate variability in chronic fatigue syndrome patients: Regulating the autonomic nervous system in a clinical randomized controlled trial. Complement Ther Med. 2025 Sep;92:103184. doi: 10.1016/j.ctim.2025.103184. Epub 2025 Apr 30. |
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| ID | Term |
|---|---|
| D015673 | Fatigue Syndrome, Chronic |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D004679 | Encephalomyelitis |
| D000090862 | Neuroinflammatory Diseases |
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| ID | Term |
|---|---|
| D015670 | Acupuncture Therapy |
| D009071 | Moxibustion |
| ID | Term |
|---|---|
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
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| moxibustion | Other | Stimulating acupoints by using burned moxa |
|
| placebo | Other | Stimulating acupoints by using stainless steel needles without manual manipulation. |
|
SF-36 consists of 36 items categorized as 8 dimensions: social functioning (2 items), role limitation-emotion (3 items), mental health (5 items), physical functioning (10 items), role limitation-physical (4 items), bodily pain (2 items), vitality (4 items), general health (5 items) and 1 question of health change in recent one year.
| Two years |
| Deficiency of Qi Scale Score (DQSS) | In DQSS, symptoms are assessed by scores ranging from 1 to 3, which stand for 'mild' to 'serious'. | Two years |
| Total Power(TP) | Total Power of heart rate variability(HRV) (ms²/Hz, %)), detected by portable HRV device. | Two years |
| Low frequency(LF) | Low frequency band (ms²/Hz, %), detected by portable HRV device. | Two years |
| High frequency (HF) | High frequency band (ms²/Hz, %), detected by portable HRV device. | Two years |
| LF/HF | Ratio of LF and HF frequency band powers (ms²/Hz, %), calculated by LF and HF results. | Two years |
| Ultra-low frequency(ULF) | Ultra-low frequency band (ms²/Hz, %),detected by portable HRV device. | Two years |
| Very low frequency | Very low frequency band (ms²/Hz, %),,detected by portable HRV device. | Two years |
| D009422 | Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |