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The herbal products on reduction of radiation-induced dermatitis in patients with breast cancer
To compare the effect of each herb extracts to protect the skin from the adverse effects of radiation therapy in patients with breast cancer with herbal extract products.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard skin care | No Intervention | standard skin care | |
| Control | Placebo Comparator | Moisture Cream |
|
| Cucumber cream | Active Comparator | Apply Cucumber cream everyday after radiation therapy on the treatment aria skin. |
|
| Centella cream | Active Comparator | Apply Centella asiatica cream everyday after radiation therapy on the treatment aria skin. |
|
| Thunbergia cream | Active Comparator | Apply Thunbergia cream everyday after radiation therapy on the treatment aria skin. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control | Other | Apply moisture cream to the treatment skin everyday after radiation therapy |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change of dermatitis grading | RTOG (Radiation Therapy Oncology Group) Cooperative Group Common Toxicity Criteria Skin Grade 0:None or no change Grade 1:Scattered macular or papular eruption or erythema that is asymptomatic Grade 2:Scattered macular or papular eruption or erythema with pruritis or other associated symptoms Grade 3:Generalized symptomatic macular, papular, or vesicular eruption Grade 4:Exfoliative dermatitis or ulcerating dermatitis Grade 5:If that toxicity caused the death of the patient. | Change from baseline dermatitis grading at 1, 2, 3, 4, 5 weeks and at 9 week. |
| Measure | Description | Time Frame |
|---|---|---|
| Patient satisfaction with the cream | Scoring 1-4
| At 9 week from date of randomization |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Saengrawee Thanthong, M.N.S. | 54 moo 4 Kampangpet 6 Taladbangken Laksi Bangkok, THAILAND 10210 | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ChulaBhorn Hospital | Bangkok | 10210 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 10443466 | Result | Chen YJ, Dai YS, Chen BF, Chang A, Chen HC, Lin YC, Chang KH, Lai YL, Chung CH, Lai YJ. The effect of tetrandrine and extracts of Centella asiatica on acute radiation dermatitis in rats. Biol Pharm Bull. 1999 Jul;22(7):703-6. doi: 10.1248/bpb.22.703. | |
| 21694984 | Result | Gohil KJ, Patel JA, Gajjar AK. Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all. Indian J Pharm Sci. 2010 Sep;72(5):546-56. doi: 10.4103/0250-474X.78519. |
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| ID | Term |
|---|---|
| D011855 | Radiodermatitis |
| D001943 | Breast Neoplasms |
| D011832 | Radiation Injuries |
| ID | Term |
|---|---|
| D003872 | Dermatitis |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| C526146 | Centella asiatica extract |
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| Cucumber cream |
| Other |
Apply cucumber cream to the treatment skin everyday after radiation therapy |
|
| Centella cream | Other | Apply centella cream to the treatment skin everyday after radiation therapy |
|
|
| Thunbergia cream | Other | Apply thunbergia cream to the treatment skin everyday after radiation therapy |
|
|
| 20118623 | Result | Haleagrahara N, Ponnusamy K. Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats. J Toxicol Sci. 2010 Feb;35(1):41-7. doi: 10.2131/jts.35.41. |
| 25525844 | Result | Johnke RM, Sattler JA, Allison RR. Radioprotective agents for radiation therapy: future trends. Future Oncol. 2014 Dec;10(15):2345-57. doi: 10.2217/fon.14.175. |
| 16893745 | Result | McQuestion M. Evidence-based skin care management in radiation therapy. Semin Oncol Nurs. 2006 Aug;22(3):163-73. doi: 10.1016/j.soncn.2006.04.004. |
| 14566480 | Result | Momm F, Weissenberger C, Bartelt S, Henke M. Moist skin care can diminish acute radiation-induced skin toxicity. Strahlenther Onkol. 2003 Oct;179(10):708-12. doi: 10.1007/s00066-003-1142-9. |
| 21153830 | Result | Nema NK, Maity N, Sarkar B, Mukherjee PK. Cucumis sativus fruit-potential antioxidant, anti-hyaluronidase, and anti-elastase agent. Arch Dermatol Res. 2011 May;303(4):247-52. doi: 10.1007/s00403-010-1103-y. Epub 2010 Dec 14. |
| 23825733 | Result | Wei LS, Wee W. Chemical composition and antimicrobial activity of Cymbopogon nardus citronella essential oil against systemic bacteria of aquatic animals. Iran J Microbiol. 2013 Jun;5(2):147-52. |
| D009371 |
| Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |