The purpose of the study is to better identify hereditary cardiac causes of sudden unexpected death in young subjects through Next-Generation Sequencing of autopsy tissue

Monitoring :

For index cases group, all the data will be monitored. For the relatives group, only the informed consent will be monitored

Statistical analysis :

• Evaluate the additional elucidation rate of unexpected sudden death
• Evaluate causes obtained by Next Generation Sequencing (NGS) ( in comparison with conventional autopsy (macroscopic and / or microscopic)
• Descriptive study of the causes of sudden unexpected death, identified hereditary cardiac causes percentages compared via various diagnostic approaches
• Cost-effectiveness analysis

Data Management :

A database is created for the AGEMOS study with control of the discrepancies. All the index cases' data entered in the data base will be double checked

Index cases :

Inclusion Criteria:

• Subjects of more than 2 years old and less than 41 years old
• Sudden unexpected death from natural and nontraumatic causes
• Macroscopic autopsy performed within 72 hours after death and without signs of body decomposition
• No extracardiac obvious causes, including toxicological analysis when available
• No significant coronary cause after autopsy (such as tight coronary stenosis, congenital abnormality of the arteries, coronary vasculitis)
• Informed consent of the close relation (family/reliable person) and / or legal representative

Relatives :

Inclusion Criteria:

• To be a first degree relative (parents, sister, brother, child) of a deceased subject included in the AGEMOS study and accept to perform medical examination and transmit results of examination

Index cases enrolled: series of consecutive and exhaustive cases recruited by forensic institutes or pathology departements Relatives enrolled: as many as possible during the recruitment period