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| ID | Type | Description | Link |
|---|---|---|---|
| NCI-2016-01214 | Registry Identifier | CTRP (Clinical Trial Reporting Program) | |
| JCCCID655 | Other Identifier | UCLA / Jonsson Comprehensive Cancer Center | |
| 16-000600 | Other Identifier | UCLA / Jonsson Comprehensive Cancer Center |
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No participants were enrolled
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This clinical trial studies how well delayed fludeoxyglucose F-18 (18F-FDG) positron emission tomography (PET)/computed tomography (CT) works in improving visualization of brain tumors in patients with glioblastoma. Radiotracers such as 18F-FDG are highly taken up by tumors in the brain and are visualized using PET/CT. Increasing the interval of time between 18F-FDG administration and PET/CT scan may improve the visualization of brain tumors in patients with glioblastoma.
PRIMARY OBJECTIVES:
I. To improve the visualization/delineation of glioblastoma lesions using delayed 18F-FDG PET/CT imaging.
OUTLINE:
Patients receive fludeoxyglucose F-18 intravenously (IV). Patients then undergo a standard of care PET/CT scan at 60 minutes and a second PET/CT scan at 240 minutes after injection.
Note:
Standard Uptake Value (SUV) is defined for state-of-the art PET/CT scanners as Standardized uptake values = count activity per ml within region of interest (MBq/ml)/[injected dose (MBq)/body weight (kgx1000)]
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diagnostic (18F-FDG PET/CT) | Patients receive fludeoxyglucose F-18 IV. Patients then undergo a standard of care PET/CT scan at 60 minutes and a second PET/CT scan at 240 minutes after injection. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Computed Tomography | Procedure | Undergo 18F-FDG PET/CT |
|
| Measure | Description | Time Frame |
|---|---|---|
| Tumor-to-background ratio on delayed scans (240 min after injection) | Ratio between Standardized uptake values (tumor region) and Standardized uptake values (physiological uptake of brain tissue) | Baseline up to 240 minutes after injection |
| Tumor-to-background ratio on standard scans (60 min after injection) | Ratio between Standardized uptake values (tumor region) and Standardized uptake values (physiological uptake of brain tissue) | Baseline up to 60 minutes after injection |
| Measure | Description | Time Frame |
|---|---|---|
| Standard uptake value comparison | Comparison of Standardized uptake values (tumor region) to visual and quantitative parameters on delayed scans (240 min after injection) | 240 minutes post injection |
| Standard uptake value comparison |
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Inclusion Criteria:
Exclusion Criteria:
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Patients older than 18 years of age who have been diagnosed with a brain tumor and are undergoing a PET/CT scan..
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| Name | Affiliation | Role |
|---|---|---|
| Johannes Czernin | UCLA / Jonsson Comprehensive Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCLA / Jonsson Comprehensive Cancer Center | Los Angeles | California | 90095 | United States |
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| ID | Term |
|---|---|
| D005909 | Glioblastoma |
| D005910 | Glioma |
| ID | Term |
|---|---|
| D001254 | Astrocytoma |
| D018302 | Neoplasms, Neuroepithelial |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
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| ID | Term |
|---|---|
| D019788 | Fluorodeoxyglucose F18 |
| D009682 | Magnetic Resonance Spectroscopy |
| ID | Term |
|---|---|
| D003847 | Deoxyglucose |
| D003837 | Deoxy Sugars |
| D002241 | Carbohydrates |
| D013057 | Spectrum Analysis |
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| Fludeoxyglucose F-18 | Radiation | Given IV |
|
|
| Positron Emission Tomography | Procedure | Undergo 18F-FDG PET/CT |
|
|
Comparison of Standardized uptake values (tumor region) to visual and quantitative parameters on standard scans (60 min after injection)
| 60 minutes post injection |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009380 | Neoplasms, Nerve Tissue |
| D002623 |
| Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |