A Phase III Study Comparing the Concurrent Versus the Sequential Administration of Chemotherapy and Aromatase Inhibitors, as Adjuvant Treatment of Post-menopausal Patients With Endocrine-responsive Early Breast Cancer.
A Phase III Study Comparing the Concurrent Versus the Sequential Administration of Chemotherapy and Aromatase Inhibitors, as Adjuvant Treatment of Post-menopausal Patients With Endocrine-responsive Early Breast Cancer.
Breast cancer is the most common form of cancer among women. For patients candidated for adjuvant chemotherapy and endocrine therapy the optimal timing for their has not been clearly defined yet.
Breast cancer is the most common form of cancer among women in North America, Europe and Latin America. Because nearly 80% of breast cancers are endocrine-responsive tumors, the majority of patients candidates for adjuvant chemotherapy (CT) are also candidates for endocrine therapy (ET). The optimal timing (i.e. concomitant vs sequential administration) for the integration of these two treatments has not been clearly defined yet.
In patients with hormone receptor positive early stage breast cancer who are candidates to adjuvant chemotherapy and endocrine therapy, the optimal timing for the integration of these two treatment modalities has not been clearly defined yet.
Inclusion Criteria:
Women with histological diagnosis of invasive breast cancer completely removed by surgery, any T, any N.
Postmenopausal status defined by at least one of the following conditions:
Aged ≥ 60
Aged 45-59 and satisfying one or more of the following criteria:
amenorrhea for ≥12 months and intact uterus;
amenorrhea for <12 months and follicle-stimulating hormone (FSH) within the postmenopausal range, including:
bilateral oophorectomy at any age >18 years.
Primary tumor positive for Estrogen Receptors (ER) and/or Progesteron receptors (PgR) (≥1% tumor cells positive by immunohistochemistry or ≥ 10 fmol/mg cytosol protein by ligand binding assay).
Patients who are prescribed 5 years of endocrine therapy with an aromatase inhibitors (AI)
Indication for adjuvant chemotherapy- Patients with HER-2 positive tumors are eligible provided that they are prescribed trastuzumab according to registered schedule.
Signed informed consent.
Exclusion Criteria:
Chieti, CH 66100, Italy
Meldola, FC 47014, Italy
Genoa, GE 16132, Italy
Isernia, IS 86170, Italy