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This study evaluates the effect of alkaline (pH=9) versus neutral (pH=9) drinking-water on the gut microbiota of healthy male volunteers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alkaline water | Experimental | Two liters (minimum) daily of alkaline drinking-water (pH=9) for 14 days |
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| Neutral Water | Active Comparator | Two liters (minimum) daily of neutral drinking-water (pH=7) for 14 days |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Alkaline drinking-water | Other |
| ||
| Neutral drinking-water |
| Measure | Description | Time Frame |
|---|---|---|
| Shannon's alpha diversity index | Diversity of the gut microbial community | Intervention day 14 |
| Measure | Description | Time Frame |
|---|---|---|
| Simpsons' reciprocal diversity index | Diversity of the gut microbial community | Intervention day 14 |
| Observed richness | Observed number of operational taxonomic units |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Oluf Pedersen, MD, DMSc | The Novo Nordisk Foundation Center for Basic Metabolic Research | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30413727 | Derived | Hansen TH, Thomassen MT, Madsen ML, Kern T, Bak EG, Kashani A, Allin KH, Hansen T, Pedersen O. The effect of drinking water pH on the human gut microbiota and glucose regulation: results of a randomized controlled cross-over intervention. Sci Rep. 2018 Nov 9;8(1):16626. doi: 10.1038/s41598-018-34761-5. |
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Anonymised datasets generated during the current study are available from the corresponding author on reasonable request
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|
| Intervention day 14 |
| Estimated richness | Number of operational taxonomic units estimated using the Chao1 method | Intervention day 14 |
| Unweighted UniFrac | Inter-individual diversity of the gut microbial community assessed using principal coordinate ordination of unweighted UniFrac distances | Intervention day 14 |
| Weighted UniFrac | Inter-individual diversity of the gut microbial community assessed using principal coordinate ordination of weighted UniFrac distances | Intervention day 14 |
| Bray-Curtis | Inter-individual diversity of the gut microbial community assessed using principal coordinate ordination of Bray-Curtis distances | Intervention day 14 |
| Operational taxonomic unit | Relative abundance of individual operational taxonomic units | Intervention day 14 |
| Bacterial genera | Relative abundance of operational taxonomic units aggregated at genus level | Intervention day 14 |
| Plasma glucose; global | Global test of intervention effect on plasma glucose concentration during an oral glucose tolerance test | Intervention day 14 |
| Serum insulin; global | Global test of intervention effect on serum insulin concentration during an oral glucose tolerance test | Intervention day 14 |
| Serum insulin; individual timepoints | Intervention effect on serum insulin concentration at individual timepoints druing an oral glucose tolerance test | Intervention day 14 |
| Plasma glucose; individual timepoints | Intervention effect on plasma glucose concentration at individual timepoints druing an oral glucose tolerance test | Intervention day 14 |
| High sensitivity C-reactive protein | Intervention day 14 |