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Multimodal brain monitoring is feasible and can be used in formulating therapeutic strategies during cardiac surgery. Such monitoring may help to improve patient outcome and to reduce costs after cardiac surgery with CPB.
The aim of this study is to use a combination of brain monitoring {Nearinfrared Spectroscopy (NIRS), Transcranial Doppler (TCD), bispectral index (BIS)} to formulate therapeutic strategies based on these monitors and to evaluate the impact on patient outcome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 (Multimodal brain monitoring) | Active Comparator | Patients will be monitored with combination of brain monitoring; Nearinfrared Spectroscopy (NIRS), Transcranial Doppler (TCD), and Bispectral index (BIS). Interference will be done to optimize the medical condition based on such monitors. |
|
| Group 2 | No Intervention | Patients will be monitored without any interference based on such monitors |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nearinfrared Spectroscopy (NIRS) | Device | Patients will be monitored and interference will be done to optimize the medical condition based on such monitor |
|
| Measure | Description | Time Frame |
|---|---|---|
| S100 protein | S100 protein (marker of brain injury) | up to 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Mini-mental state examination | up to 30 days after surgery | |
| Western perioperative neurological scale | up to 30 days after surgery | |
| Major neurological out come as stoke |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mohamed Ali, PhD. MD | Contact | 0020882413201 | msali58@hotmail.com | |
| Sayed K Abd-Elshafy, MD | Contact | 0020882413201 | sayed_k_72@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Mohamed Ali, PhD. MD | associate professor of anesthesia and critical care | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of medicine Assiut University | Recruiting | Asyut | 74111 | Egypt |
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| ID | Term |
|---|---|
| D017585 | Ultrasonography, Doppler, Transcranial |
| D056805 | Consciousness Monitors |
| ID | Term |
|---|---|
| D004453 | Echoencephalography |
| D009485 | Neuroradiography |
| D059906 | Neuroimaging |
| D003952 | Diagnostic Imaging |
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| Transcranial Doppler (TCD) | Device | Patients will be monitored and interference will be done to optimize the medical condition based on such monitor |
|
| Bispectral index (BIS) | Device | Patients will be monitored and interference will be done to optimize the medical condition based on such monitor |
|
| up to 30 days after surgery |
| Duration of mechanical ventilation | up to 30 days after surgery |
| Hospital stay | up to 30 days after surgery |
| D019937 |
| Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011859 | Radiography |
| D014463 | Ultrasonography |
| D018608 | Ultrasonography, Doppler |
| D003943 | Diagnostic Techniques, Neurological |
| D008919 | Investigative Techniques |
| D013523 | Surgical Equipment |
| D004864 | Equipment and Supplies |