Stroke remains one of the most devastating neurological diseases, often causing death, or gross physical impairment. It is the second most common cause of death worldwide and a major cause of acquired disability in adults.Vitamin D deficiency has been reported to contribute to the risk of cardiovascular disease especially stroke.

This case -control observational prospective study will conducted on fifty patients with first -ever acute onset stroke within seven days (25 patients with hemorrhagic stroke and 25 patients with ischemic stroke )

Inclusion Criteria:

• Onset is within one week
• Confirmed stroke by brain CAT and / or MRI scan either haemorrhage or infarction

Exclusion Criteria:

• Cognitive and mental changes
• Recurrent stroke
• Hepatic and renal impairment
• Endocrinal diseases
• Steroid therapy
• Vitamin D or Ca supplementation
• Previous fractures
• Bone diseases
• brain neoplasm,
• Autoimmune diseases
• History of acute and chronic inflammatory diseases
• Malignancy,
• Trauma
• Surgery
• Acute vascular diseases that occurred within four weeks prior the onset of stroke
• History myocardial infarction ˂3 months.

patients with first -ever acute onset stroke within seven days