HMGB1 in ICU-survivors

Cognitive Impairment After Critical Illness, Links Between Sepsis, Cognitive Function and Non-resolving Inflammation

Is HMGB1 (High Mobility Group Box 1) elevated in sepsis patients for weeks after recovery from severe sepsis/septic shock, similar to what has been observed in mice? Do patients recovering from severe sepsis/septic shock suffer from cognitive impairment and is such impairment associated with prolonged HMGB1 levels in plasma? Is there a difference from patients recovering from critical illness without prior sepsis?

Inclusion Criteria:

• Male/Female age 18-17
• Expected ICU-stay more than 24 hours

Exclusion Criteria:

• Dont understand the language
• Substance abuse, alcohol or drugs
• Blind, deaf or suffering from aphasia
• Ongoing psychiatric illness or psychopharmacological treatment
• Suffering from dementia och mentally impaired
• Structured brain damage or meningitis
• Palliative Care
• ICU-treated for more than 48 hours
• Transferred from other ICU
• Being treated with ECMO
• Not having residency in Stockholm