A Study Comparing Green Fluorescent Dye and Radioactive Dye for Sentinel Lymph Node Biopsy in Pediatric Cancers

Non-inferiority Study of Intra-operative Indocyanine Green Fluorescent Dye Versus Technetium Lymphoscintigraphy for Sentinel Lymph Node Biopsy in Pediatric Malignancies

This study is being done in patients that have tumors to find out how well sentinel lymph nodes (SLNs) can be found with a special dye called indocyanine green (ICG).

Inclusion Criteria:

• Patients <30 years old with an extracoelomic solid tumor, diagnosis confirmed at the enrolling institution, requiring SLN biopsy
• Women of childbearing potential must have a negative pregnancy test (urine or blood) pre-operatively as per the standard hospital policy. A woman of childbearing potential is defined as one who is biologically capable of becoming pregnant.
• Patients who are cleared for surgery

Exclusion Criteria:

• History of reaction to ICG, iodides, or technetium radiocolloid
• Intracoelomic primary tumors or tumors expected to drain to an intracoelomic SLN
• Patients with extensive prior surgery at the primary site or nodal basin expected to affect the lymphatic drainage
• Patients unwilling or unable to sign informed consent
• Women who are pregnant or breast-feeding