Priming of Cardiopulmonary Bypass With Hydroxyethyl Starch 130/0.4 or Sodium Chloride 0.9% : Pilot Study in Adult Elective Conventional Cardiac Surgery

Priming of Cardiopulmonary Bypass With Hydroxyethyl Starch 130/0.4 or Sodium Chloride 0.9% : a Double Blind Randomized Pilot Study in Adult Elective Conventional Cardiac Surgery

Best priming for cardiopulmonary bypass in cardiac surgery is unknown. Efficacy and toxicity of Hydroxyethyl Starch 130/0.4 used in this context are uncertain.

The aim of this pilot study is to determine if Hydroxyethyl Starch 130/0.4 is more effective than Sodium Chloride 0.9% in short term hemodynamic purpose without side renal or hemostatic effect.

Inclusion Criteria:

• Patients scheduled for elective conventional cardiac surgery with cardiopulmonary bypass
• Patients insured under the French social security system

Exclusion Criteria:

• Pregnancy
• Patients placed under guardianship
• Urgent surgery
• Cardiac surgery without cardiopulmonary bypass
• Anterior cardiac surgery
• Non conventional cardiac surgery (mini-invasive surgery, dual valve replacement, right heart surgery)
• Simultaneous inclusion in another study with potential interference in outcomes
• Heparin-induced thrombocytopenia
• Chronic renal insufficiency (glomerular filtration rate < 60mL.min-1.m-2)
• Nature/nurture hemostasis disorders, in particular Von Willebrand disease and hemophilia
• Hydroxyethyl Starch allergy
• Weight under 33 kg
• Mechanical hemodynamic support at the end of the surgery