Local Administration of Tranexamic Acid in Upper Gastrointestinal Hemorrhage

Local Administration of Tranexamic Acid in Upper Gastrointestinal Hemorrhage: A Double-Blind, Randomized, Placebo-Controlled Trial

Upper gastrointestinal hemorrhage is a frequently diagnosis in emergency departments. Although new drugs and endoscopic techniques were easily applied in various settings in this condition, the role of local administered therapies such as antifibrinolytic agents remain unclear. The investigators aimed to compare standard therapy (proton pump inhibitors, endoscopic treatments etc.) and standard therapy + local administered tranexamic acid in upper gastrointestinal hemorrhage in a double-blind, randomized trial.

Inclusion Criteria:

• Patients presenting with upper gastrointestinal hemorrhage to the ED
• Patients older than 18 years
• Patients who agree to participate the study by reading and signing the informed consent form

Exclusion Criteria:

• Patients younger than 18 years
• Patients who do not agree to participate the study
• Documented or declared allergy to tranexamic acid
• Upper gastrointestinal hemorrhage secondary to trauma
• Upper gastrointestinal hemorrhage secondary to esophageal varices
• Patients who cannot undergo to endoscopy for any reason
• History for thromboembolic disease
• Patients with renal impairment