Efficacy and Safety of Hourly Titrated Misoprostol Versus Vaginal Dinoprostone and Misoprostol for Cervical Ripening and Labor Induction

Efficacy and Safety of Hourly Titrated Misoprostol Versus Vaginal Dinoprostone and Misoprostol for Cervical Ripening and Labor Induction: Randomized Clinical Trial

This study evaluates the efficacy and safety of the administration of oral misoprostol versus vaginal dinoprostone and vaginal misoprostol for cervical ripening and labor induction.

Inclusion Criteria:

• Women over 18
• single pregnancy
• cephalic presentation
• intact membranes
• unfavorable cervix ( less than 6 Bishop )
• CTGR not reactive decelerative
• Signed informed consent by the patient.

Exclusion Criteria:

• prior Cesarean section or previous uterine surgery .
• Allergy or intolerance to any of the study drugs
• stillbirth
• uterine growth restricted fetuses
• contraindication for vaginal delivery
• Anterior placenta
• Multiparity
• moderate to severe heart disease
• hypertensive disorders of pregnancy
• Suspected chorioamnionitis
• Coagulation disorders
• history of epileptic seizures
• liver or kidney disease
• Cognitive impairment or bad knowledge of Spanish