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Eighty community-living individuals in Uppsala municipality will be included. Intervention: Outdoor walking exercise program and one strength exercise. Methods: Clinical assessments, questionnaires and medical records. Assessment of motor function, cognition, level of physical activity, food intake and perceived stress are performed at screening as baseline measurements. Walking capacity, mobility, handgrip strength, body composition and cardiovascular risk markers will be assessed at baseline and after 12 week of training. At one year after training health-related quality of life, another cardiovascular incidence and mortality will be documented.
Eighty community-living individuals in Uppsala municipality will be included in a randomized controlled trial with two arms.
Intervention: Participants will perform an outdoor walking exercise program together with one strength exercise for 12 weeks. The intensity and frequency of the training will progressively increase. Participants are supposed to walk and perform strength training 5-7 days/week.
Methods: Clinical assessments, questionnaires and medical records used for documentation of age, sex, comorbidity, blood pressure, medications and previous education.
Assessment of motor function, cognition, level of physical activity, food intake and perceived stress are performed at screening as baseline measurements. Walking capacity (primary outcome measure), mobility, handgrip strength, body composition and cardiovascular risk markers will be assessed at baseline and after 12 week of training. At one year after training health-related quality of life, another cardiovascular incidence and mortality will be evaluated.
Power analysis is performed. The investigators will analyze the data using an intention-to -treat analysis. Participants should have participated in at least 50% of the training sessions
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention: | Experimental | Outdoor walking and strength exercise, Three months, daily SMS. |
|
| Control group | Other | Usual care; no restriction for exercise, Three months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Outdoor walking and strength exercise | Other | Exercise group: Participants are supposed to perform an outdoor walking exercise program and one strength exercise for 12 weeks. The first 2 weeks start with daily walks. The intensity and frequency of walks will progressively increase performed according to the Borg scale: 12-15, ie, moderate to strenuous. Participants will walk 5-7 days/week. Added to this is a strength exercise, i.e. chair-rising which also should be performed daily. |
| Measure | Description | Time Frame |
|---|---|---|
| 6 minute walk test (6MWT) | walking capacity | from baseline walking capacity to three months |
| Measure | Description | Time Frame |
|---|---|---|
| Short Physical Performance Battery (SPPB) | mobility | from baseline SPPB to three months |
| 10 meter walk test (10mWT) | gait speed | from baseline 10mWT to three months |
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Inclusion Criteria:
Exclusion Criteria:
One or more of the following:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Birgit Vahlberg, Med Dr, RPT | Contact | +46709583473 | birgit.vahlberg@pubcare.uu.se | |
| Tommy Cederholm, Professor,MD | Contact | +46702733192 | tommy.cederholm@pubcare.uu.se |
| Name | Affiliation | Role |
|---|---|---|
| Birgit Vahlberg | Sweden,Uppsala Uppsala University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Birgit Vahlberg | Recruiting | Uppsala | 75185 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38443081 | Derived | Vahlberg BM, Eriksson S, Holmback U, Lundstrom E. Factors associated with changes in walking performance in individuals 3 months after stroke or TIA: secondary analyses from a randomised controlled trial of SMS-delivered training instructions in Sweden. BMJ Open. 2024 Mar 4;14(3):e078180. doi: 10.1136/bmjopen-2023-078180. | |
| 34663672 |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 1, 2022 | |
| Reset | Sep 13, 2023 | |
| Release | Oct 3, 2023 | |
| Reset | Apr 11, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 1, 2022 | Sep 13, 2023 | |||
| Oct 3, 2023 |
| ID | Term |
|---|---|
| D020521 | Stroke |
| D002546 | Ischemic Attack, Transient |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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|
|
| control group | Other | Control-Group: Treatment as usual for 12 weeks, without restriction of being physically active. |
|
|
| Hand-dynamometer (Jamar) | hand-grip strength | from baseline Jamar to three months |
| Body composition (bioelectric impedance analysis) | muscles and fat mass and BMI | from baseline body composition to three months |
| Cardiometabolic risk markers | blood lipids, c-reactive proteins (CRP), blood glukos, HbA1c, Insulin-like growth factor (IGF-1), Interleukin-6 (Il-6) | from baseline cardiometabolic risk markers to three months |
| Heart and lung foundation stress test | self-perceived stress | at baseline |
| Food frequency questionnaire | self-reported food intake and quality | at baseline |
| Montreal outcome assessment (MoCA) | cognition | at baseline |
| Modified rankin scale (MRS) | motor function | at baseline |
| Mortality | register-based mortality | from baseline to 1 year |
| Health-related quality of life | register-based quality of life | from baseline to 1 year |
| Vahlberg BM, Lundstrom E, Eriksson S, Holmback U, Cederholm T. Potential effects on cardiometabolic risk factors and body composition by short message service (SMS)-guided training after recent minor stroke or transient ischaemic attack: post hoc analyses of the STROKEWALK randomised controlled trial. BMJ Open. 2021 Oct 18;11(10):e054851. doi: 10.1136/bmjopen-2021-054851. |
| 32942914 | Derived | Vahlberg B, Lundstrom E, Eriksson S, Holmback U, Cederholm T. Effects on walking performance and lower body strength by short message service guided training after stroke or transient ischemic attack (The STROKEWALK Study): a randomized controlled trial. Clin Rehabil. 2021 Feb;35(2):276-287. doi: 10.1177/0269215520954346. Epub 2020 Sep 18. |
| Apr 11, 2024 |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D002545 | Brain Ischemia |
| D001519 | Behavior |
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
| D008722 | Methods |