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The French DIVAT (standing for Données Informatisées et VAlidées en Transplantation in french, and in English "Computerized and VAlidated Data in Transplantation" ) cohort was Kicked off in 1994 by the Transplantation Urology Nephrology Institute of the Nantes University Hospital in France. The primary objective of this multicenter computerized database was to enable prospective clinical and epidemiological research studies concerning kidney transplant recipients, particularly focusing on mid- and long-term clinical outcomes, therapeutic strategies and public health issues. The patient-case system of the DIVAT cohort allows the monitoring of medical records of all patient-specific and allograft-specific data, including bio-banking since 2005. Data are collected from the date of transplantation until the graft failure, at each scheduled outpatient visit or hospital admission motivating by a new clinical, therapeutical or biological expression. The DIVAT cohort contains information on more than 11000 transplant recipients between 1994 and today, issued from 8 French university hospitals centers (the DIVAT Network is organized by a consortium agreement). 18% of all patients underwent retransplantation and 11% of all kidney transplants originated from living donors. The DIVAT network heavily works to ensure a high-quality data collection with the aim of exploring adequately the complex post-transplantation process. The Divat network encourage collaborations and enables interested researchers to submit a research project by completing a request form available on the DIVAT website (http://www.divat.fr/en) describing the context, objectives and design of the study
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients with kidney transplantations | patients with kidney transplantations |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| kidney transplantation | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of participants with Overall Survival | 2 years | |
| Proportion of participants with Overall Survival | 4 years | |
| Proportion of participants with Overall Survival | 6 years |
| Measure | Description | Time Frame |
|---|---|---|
| expansion of effector memory CD8+ T cells dosage | potential marker for acute graft dysfunction | 1 year |
| expansion of effector memory CD8+ T cells dosage | potential marker for late graft dysfunction |
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Inclusion Criteria:
Exclusion Criteria:
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Eight French transplantation centers participate to the DIVAT network: Nantes, Paris Necker, Nancy and Montpellier since 1994, Toulouse since 1997, Lyon since 2006, and Paris Saint-Louis and Nice that joined the network since 2013. All patients over the age of 18 years, who received a renal transplant, are included. No other particular inclusion criteria exist.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Magali Giral, PU-PH | Contact | +33 (0)2 40 08 74 43 | mgiral@chu-nantes.fr |
| Name | Affiliation | Role |
|---|---|---|
| Magali Giral, PU-PH | Nantes Universuty Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Docteur Buron | Recruiting | Lyon | 69002 | France | ||
| Professeur Mourad |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41591822 | Derived | Berthelot L, Degauque N, Cappelier L, Sailliet N, Mathe C, Brinas F, Dupuy A, Boussamet L, Tilly G, Colas L, Chesneau M, Kerleau C, Giral M, Danger R, Mai HL, Yeremenko N, Brouard S; Divat Consortium. IgA-Producing B Cells Exert Regulatory Function through Granzyme B in Kidney Allograft Tolerance. Kidney360. 2026 Jun 1;7(6):1251-1261. doi: 10.34067/KID.0000001054. Epub 2026 Jan 27. | |
| 41340865 |
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peripheral blood cells, serum, plasma, urine, m-RNA, and DNA of recipients and donors
| 6 years |
| Recruiting |
| Montpellier |
| 34295 |
| France |
| Professeur Kessler | Recruiting | Nancy | 54035 | France |
| Professeur Ladriere | Recruiting | Nancy | 54035 | France |
| Pr Cassuto | Recruiting | Nice | 06003 | France |
| Professeur Kreis | Recruiting | Paris | 75184 | France |
| Professeur Legendre | Recruiting | Paris | 75184 | France |
| Professeur Rostaing | Recruiting | Toulouse | 31400 | France |
| Derived |
| Maanaoui M, Lenain R, Petit V, Dujardin A, Morelon E, Charmetant X, Le Quintrec M, Serre JE, Ladriere M, Girerd S, Masset C, Sicard A, Gosset C, Hamroun A, Kerleau C, Garandeau C, Provot F, Giral M, Hazzan M; DIVAT Consortium. Donor Characteristics Associated With Graft Loss and Delayed Graft Function in Very-Aged Kidney Donors: An Observational Multicentric Study. Transpl Int. 2025 Nov 18;38:14862. doi: 10.3389/ti.2025.14862. eCollection 2025. |
| 40653616 | Derived | Choisy C, Foucher Y, Masset C, Maanaoui M, Lenain R, Rostaing L, Jouve T, Le Quintrec M, Serre JE, Morelon E, Charmetant X, Ladriere M, Girerd S, Sicard A, Gosset C, Mariat C, Claisse G, Giral M, Dantan E; DIVAT Consortium. Identification of Donor-recipient Interactions for a Relative Appraisal of Kidney Graft Marginality: A French Multicentric Cohort-based Study. Transplantation. 2025 Dec 1;109(12):e708-e717. doi: 10.1097/TP.0000000000005464. Epub 2025 Jul 14. |
| 36990211 | Derived | Danger R, Le Berre L, Cadoux M, Kerleau C, Papuchon E, Mai HL, Nguyen TV, Guerif P, Morelon E, Thaunat O, Legendre C, Anglicheau D, Lefaucheur C, Couzi L, Del Bello A, Kamar N, Le Quintrec M, Goutaudier V, Renaudin K, Giral M, Brouard S; DIVAT Consortium. Subclinical rejection-free diagnostic after kidney transplantation using blood gene expression. Kidney Int. 2023 Jun;103(6):1167-1179. doi: 10.1016/j.kint.2023.03.019. Epub 2023 Mar 27. |
| ID | Term |
|---|---|
| D016030 | Kidney Transplantation |
| ID | Term |
|---|---|
| D017582 | Renal Replacement Therapy |
| D013812 | Therapeutics |
| D016377 | Organ Transplantation |
| D014180 | Transplantation |
| D013514 | Surgical Procedures, Operative |
| D013520 | Urologic Surgical Procedures |
| D013519 | Urogenital Surgical Procedures |
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