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The MecoExpo project seeks to evaluate the in utero exposure of newborns in the Picardie region to commonly used pesticides. These pesticides were selected in a pilot study (the Mecopic study) on the basis of their toxicity (effects on foetal development, endocrine perturbation, neurological toxicity and carcinogenicity) and a certain number of indicators of pesticide use and the presence of pesticide in the environment in Picardie.
These substances (or their metabolites) will be measured in the each newborn's meconium (the first faeces after birth) and each newborn's mother's hair in the Picardie region during the study period. The mother's exposure will also be assessed using a retrospective questionnaire (filled out within a few days of the delivery).
Thus, the MecoExpo project will enable the investigators to:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| meconium | Experimental | The meconium will be sampled in the first 2 days of life |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| meconium | Other | The meconium will be sampled in the first 2 days of life |
|
| Measure | Description | Time Frame |
|---|---|---|
| fœtal vs mother exposure - term | evaluate the relationships between foetal exposure (via the meconium), maternal exposure (via the hair and the questionnaire) and term at birth | Day 2 |
| fœtal vs mother exposure - length | evaluate the relationships between foetal exposure (via the meconium), maternal exposure (via the hair and the questionnaire) and length at birth | Day 2 |
| fœtal vs mother exposure - weight | evaluate the relationships between foetal exposure (via the meconium), maternal exposure (via the hair and the questionnaire) and weight at birth | Day 2 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Caroline DEGUINES, MD | CHU Amiens | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CH Abbeville | Abbeville | 80142 | France | |||
| CHU Amiens |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24949871 | Result | Mayhoub F, Berton T, Bach V, Tack K, Deguines C, Floch-Barneaud A, Desmots S, Stephan-Blanchard E, Chardon K. Self-reported parental exposure to pesticide during pregnancy and birth outcomes: the MecoExpo cohort study. PLoS One. 2014 Jun 20;9(6):e99090. doi: 10.1371/journal.pone.0099090. eCollection 2014. |
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| Amiens |
| 80054 |
| France |
| Groupe Santé Victor Pauchet | Amiens | 80094 | France |
| CH Beauvais | Beauvais | 60021 | France |
| CH Chauny | Chauny | 02303 | France |
| CH Chateau-Thierry | Château-Thierry | 02405 | France |
| Clinique Saint Come | Compiègne | 60200 | France |
| CH Compiegne | Compiègne | 60321 | France |
| Groupe Hospitalier Public Sud Oise | Creil | 60109 | France |
| CH Laon | Laon | 02001 | France |
| CH Peronne | Péronne | 80201 | France |