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| ID | Type | Description | Link |
|---|---|---|---|
| 1R01CA201873-01A1 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
| National Institutes of Health (NIH) | NIH |
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The investigators propose an innovative full-factorial design in a cohort of 1056 adult smokers in an urban emergency department (ED), to test the efficacy of four key intervention components: motivational interviewing, medication, quitline referral, and texting. At the trial's completion, a mixed-methods approach will be used to identify the components that were efficacious within the proposed cost constraint, along with feasibility and acceptability to providers and subjects. The investigators will then assemble an intervention that maximizes efficacy, given a cost-effectiveness constraint and findings from a qualitative analysis.
The investigators propose to optimize the identification and treatment of adult smokers seen in a hospital ED. To do this the Multiple Optimization Strategy (MOST) will be employed to develop a multicomponent intervention that will consist of some combination of the following: (1) a Brief Negotiation Interview (BNI, a variant of a motivational interview), delivered by a trained research assistant; (2) provision of 6 weeks of nicotine patches and gum to the research participant, with application of the first patch in the ED (NRT); (3) active referral to the Connecticut Smokers' Quitline (QL); and (4) enrollment in the SmokefreeText a short-messaging service (SMS) texting program for mobile phones (Text). Using MOST principles, the first phase of the study will use a 2x2x2x2 full-factorial design to identify the components most likely to be efficacious in combination. Although the factorial design requires the allocation of participants to 16 different combinations of the 4 components (Table 1), evaluation of each individual component is performed comparing all of those receiving a component to all of those not receiving a component, making this an efficient design. For instance, evaluation of the BNI component will compare those randomized to arms 1 through 8 to those in arms 9 to 16.The second phase will consist of designing and proposing a 2-arm randomized clinical trial comparing the efficacy of the multicomponent intervention package to usual care; this will be conducted in a future application.
The specific aims of this proposed study are:
Aim 1. To conduct a fully powered factorial randomized trial of 1056 adult smokers to test the efficacy of 4 key components of ED-initiated tobacco treatment: Brief Negotiated Interview (BNI), nicotine replacement therapy (NRT), Quitline referral (QL), and SmokeFreeText (Text).
Aim 2. To identify the most efficacious components of our intervention, within fixed constraints of cost effectiveness and feasibility/acceptability to providers and subjects.
Aim 3. To lay the groundwork for a future randomized trial testing the previously identified components, delivered as a package, against a control arm in a new cohort of adult ED smokers.
Our associated hypotheses are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| BNI+NRT+QL+Text | Experimental | Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text) |
|
| BNI+NRT+QL | Experimental | Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) |
|
| BNI+NRT+Text | Experimental | Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Registration in SmokefreeText (Text) |
|
| BNI+NRT | Experimental | Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply |
|
| BNI+QL+Text |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Brief Negotiated Interview (BNI) | Behavioral | Brief motivational interview on smoking behavior |
|
| Measure | Description | Time Frame |
|---|---|---|
| Tobacco Abstinence | Abstinence self reported and verified by exhaled carbon monoxide | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Steven L Bernstein, MD | Yale School of Medicine, Department of Emergency Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yale School of Medicine | New Haven | Connecticut | 06519 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29287665 | Derived | Bernstein SL, Dziura J, Weiss J, Miller T, Vickerman KA, Grau LE, Pantalon MV, Abroms L, Collins LM, Toll B. Tobacco dependence treatment in the emergency department: A randomized trial using the Multiphase Optimization Strategy. Contemp Clin Trials. 2018 Mar;66:1-8. doi: 10.1016/j.cct.2017.12.016. Epub 2017 Dec 27. |
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| ID | Title | Description |
|---|---|---|
| FG000 | NRT+QL+Text | Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text) Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
| FG001 | BNI+QL+Text | Brief Negotiated Interview (BNI) Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
| FG002 | BNI+NRT+QL+Text | Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
| FG003 | NRT+QL | Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. |
| FG004 | BNI+QL | Brief Negotiated Interview (BNI) Referral to CT Smokers Quitline (QL) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. |
| FG005 | NRT Only | Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. |
| FG006 | BNI+Text | Brief Negotiated Interview (BNI) Registration in SmokefreeText (Text) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
| FG007 | BNI+NRT+Text | Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Registration in SmokefreeText (Text) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
| FG008 | NRT+Text | Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Registration in SmokefreeText (Text) Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
| FG009 | BNI+NRT | Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. |
| FG010 | Control | Control arm, no intervention |
| FG011 | BNI+NRT+QL | Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. |
| FG012 | Text Only | Registration in SmokefreeText (Text) SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
| FG013 | QL+Text | Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text) CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
| FG014 | BNI Only | Brief Negotiated Interview (BNI) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior |
| FG015 | QL Only | Referral to CT Smokers Quitline (QL) CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline |
| |||||||||||||
| 1 Month Follow-up |
| |||||||||||||
| 3 Month Follow-up |
| |||||||||||||
| Biochemical Verification at 3 Months |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | NRT+QL+Text | Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text) Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Tobacco Abstinence | Abstinence self reported and verified by exhaled carbon monoxide | All participants eligible for 3 month follow-up (deceased participants excluded). Each intervention group was compared with all participants who did not receive that intervention. The comparison group therefore differed for each intervention: BNI=526; NRT=525; QL=527; Text = 526. | Posted | Count of Participants | Participants | 3 months |
|
Each participant was monitored for adverse events for 3 months.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | NRT+QL+Text | Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text) Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Steven L. Bernstein, MD | Yale School of Medicine | 203-737-3574 | steven.bernstein@yale.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Feb 28, 2020 | Aug 13, 2020 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D014029 | Tobacco Use Disorder |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D000095488 | Nicotine Replacement Therapy |
| ID | Term |
|---|---|
| D004358 | Drug Therapy |
| D013812 | Therapeutics |
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| Experimental |
Brief Negotiated Interview (BNI) Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text) |
|
| BNI+QL | Experimental | Brief Negotiated Interview (BNI) Referral to CT Smokers Quitline (QL) |
|
| BNI+Text | Experimental | Brief Negotiated Interview (BNI) Registration in SmokefreeText (Text) |
|
| BNI only | Experimental | Brief Negotiated Interview (BNI) |
|
| NRT+QL+Text | Experimental | Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text) |
|
| NRT+QL | Experimental | Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) |
|
| NRT+Text | Experimental | Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Registration in SmokefreeText (Text) |
|
| NRT only | Experimental | Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply |
|
| QL+Text | Experimental | Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text) |
|
| QL only | Experimental | Referral to CT Smokers Quitline (QL) |
|
| Text only | Experimental | Registration in SmokefreeText (Text) |
|
| Control | No Intervention | Control arm, no intervention |
| Nicotine replacement therapy (NRT) | Drug | 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. |
|
| CT Smokers Quitline (QL) | Other | Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. |
|
| SmokefreeText (Text) | Other | Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
|
| COMPLETED |
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| NOT COMPLETED |
|
|
| COMPLETED |
|
| NOT COMPLETED |
|
|
| COMPLETED | Only participants reporting abstinence at the 3m follow-up complete the biochem. |
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| NOT COMPLETED |
|
|
| BG001 | BNI+QL+Text | Brief Negotiated Interview (BNI) Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
| BG002 | BNI+NRT+QL+Text | Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
| BG003 | NRT+QL | Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. |
| BG004 | BNI+QL | Brief Negotiated Interview (BNI) Referral to CT Smokers Quitline (QL) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. |
| BG005 | NRT Only | Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. |
| BG006 | BNI+Text | Brief Negotiated Interview (BNI) Registration in SmokefreeText (Text) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
| BG007 | BNI+NRT+Text | Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Registration in SmokefreeText (Text) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
| BG008 | NRT+Text | Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Registration in SmokefreeText (Text) Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
| BG009 | BNI+NRT | Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. |
| BG010 | Control | Control arm, no intervention |
| BG011 | BNI+NRT+QL | Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. |
| BG012 | Text Only | Registration in SmokefreeText (Text) SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
| BG013 | QL+Text | Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text) CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. |
| BG014 | BNI Only | Brief Negotiated Interview (BNI) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior |
| BG015 | QL Only | Referral to CT Smokers Quitline (QL) CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. |
| BG016 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Ethnicity (NIH/OMB) | Count of Participants | Participants |
|
| Race (NIH/OMB) | Count of Participants | Participants |
|
| Region of Enrollment | Count of Participants | Participants |
|
| Cigarettes per Day (CPD) | Number of cigarettes smoked per day at baseline | Median | Inter-Quartile Range | cigarettes per day |
|
| Heaviness of Smoking Index >=4 | Heaviness of Smoking Index score derived from 2 questions:
SCORING: 0-2: low addiction 3-4: moderate addiction 5-6: high addiction | Number | participants |
|
All 8 arms which did not include the BNI intervention: NRT+QL+Text NRT+QL NRT+Text NRT QL+Text QL Text Control |
| OG002 | Nicotine Replacement Therapy (NRT) | All 8 arms with Nicotine Replacement Therapy as an intervention: NRT only Brief Negotiated Interview (BNI)+NRT NRT+Quitline (QL) NRT+Text BNI+NRT+QL BNI+NRT+Text NRT+QL+Text BNI+NRT+QL+Text |
| OG003 | Nicotine Replacement Therapy (NRT) CONTROL | All 8 arms which did not include the NRT intervention: BNI+QL+Text BNI+QL BNI+Text BNI Only QL+Text QL Only Text Only Control |
| OG004 | Quitline (QL) | All 8 arms with the Quitline as an intervention: QL only Brief Negotiated Interview (BNI)+QL Nicotine Replacement Therapy (NRT)+QL QL+Text BNI+NRT+QL BNI+QL+Text NRT+QL+Text BNI+NRT+QL+Text |
| OG005 | Quitline (QL) CONTROL | All 8 arms which did not include the QL intervention: BNI+NRT+Text BNI+NRT BNI+Text BNI Only NRT+Text NRT Only Text Only Control |
| OG006 | Text | All 8 arms with Text as an intervention: Text only Brief Negotiated Interview (BNI)+Text Nicotine Replacement Therapy (NRT)+Text Quitline (QL)+Text BNI+NRT+Text BNI+QL+Text NRT+QL+Text BNI+NRT+QL+Text |
| OG007 | Text CONTROL | All 8 arms which did not include the Text intervention: BNI+NRT+QL BNI+NRT BNI+QL BNI Only NRT+QL NRT Only QL Only Control |
|
|
|
| 0 |
| 66 |
| 0 |
| 66 |
| 0 |
| 66 |
| EG001 | BNI+QL+Text | Brief Negotiated Interview (BNI) Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. | 0 | 66 | 0 | 66 | 0 | 66 |
| EG002 | BNI+NRT+QL+Text | Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. | 0 | 66 | 0 | 66 | 0 | 66 |
| EG003 | NRT+QL | Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. | 0 | 66 | 0 | 66 | 0 | 66 |
| EG004 | BNI+QL | Brief Negotiated Interview (BNI) Referral to CT Smokers Quitline (QL) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. | 0 | 66 | 0 | 66 | 0 | 66 |
| EG005 | NRT Only | Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. | 0 | 66 | 0 | 66 | 0 | 66 |
| EG006 | BNI+Text | Brief Negotiated Interview (BNI) Registration in SmokefreeText (Text) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. | 0 | 66 | 0 | 66 | 0 | 66 |
| EG007 | BNI+NRT+Text | Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Registration in SmokefreeText (Text) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. | 0 | 66 | 0 | 66 | 0 | 66 |
| EG008 | NRT+Text | Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Registration in SmokefreeText (Text) Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. | 0 | 66 | 0 | 66 | 0 | 66 |
| EG009 | BNI+NRT | Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. | 0 | 66 | 0 | 66 | 0 | 66 |
| EG010 | Control | Control arm, no intervention | 0 | 66 | 0 | 66 | 0 | 66 |
| EG011 | BNI+NRT+QL | Brief Negotiated Interview (BNI) Nicotine replacement therapy (NRT) patches and gum, 6 weeks supply Referral to CT Smokers Quitline (QL) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior Nicotine replacement therapy (NRT): 6 weeks of nicotine replacement, patches and gum. First dose of each started in ED. Patches are 14mg or 21 mg. Gum is 2mg per piece. CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. | 0 | 66 | 0 | 66 | 0 | 66 |
| EG012 | Text Only | Registration in SmokefreeText (Text) SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. | 0 | 66 | 0 | 66 | 0 | 66 |
| EG013 | QL+Text | Referral to CT Smokers Quitline (QL) Registration in SmokefreeText (Text) CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. SmokefreeText (Text): Enrollment in a version of NCI's SmokefreeTxt, tailored for the study. | 1 | 66 | 0 | 66 | 0 | 66 |
| EG014 | BNI Only | Brief Negotiated Interview (BNI) Brief Negotiated Interview (BNI): Brief motivational interview on smoking behavior | 1 | 66 | 0 | 66 | 0 | 66 |
| EG015 | QL Only | Referral to CT Smokers Quitline (QL) CT Smokers Quitline (QL): Faxed referral to the CT Smokers Quitline for the subject. QL will then call subject to offer phone based counseling. | 1 | 66 | 0 | 66 | 0 | 66 |
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