Home-Administered Trial of Direct Current Stimulation

Home-administered Transcranial Direct Current Stimulation (tDCS) Treatment for Depression

Transcranial Direct Current Stimulation (tDCS) is a novel non-invasive brain stimulation treatment that is effective with no significant side effects. It can potentially be self-administered by patients in their own homes with remote monitoring, substantially reducing treatment costs and increasing accessibility, including to remote areas. This study will evaluate the feasibility and efficacy of home-administered tDCS treatment for depression.

Inclusion Criteria:

• Subject meets criteria for a DSM-IV Major Depressive Episode, lasting more than 4 weeks
• Total MADRS score ≥ 20

Exclusion Criteria:

• Diagnosis of any DSM-IV psychotic disorder
• History of drug or alcohol abuse or dependence in the preceding 3 months
• High suicide risk
• Clinically defined neurological disorder or insult
• Metal in the cranium or skull defects
• Skin lesions on the scalp (e.g. cuts, abrasions, rashes) at the proposed electrode sites
• Pregnancy