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The dissemination of individual tumor cells is a common phenomenon in solid cancers. Detection of tumor cells in peripheral blood circulating tumor cells (CTC) in nonmetastatic situation is of high prognostic significance.
The objective of our study was to detect circulating tumor cells in two different method in patient with head and neck squamous cell carcinoma .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| experimental | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Circulating Tumor Cells | Other | Patients with stage III and IV head and neck squamous cell carcinoma undergoing surgery were enrolled in this study 5 and 7.5 ml of peripheral venous blood will be taken before the surgery, just at the end of surgery and one week after surgery Analysis was performed by RT-PCR and the CellSearchâ„¢ method using immunomagnetic and fluorescence approaches. Patients will be followed every 3 months for two years. |
| Measure | Description | Time Frame |
|---|---|---|
| Circulating tumor cells in peripheral blood during head and neck surgery | The number of circulating tumor cells detected per milliliter of peripheral blood will be evaluated on the day before, the day of surgery and 7 days after the surgery. | 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison between RT-PCR and CellSearchâ„¢ method | The comparison between RT-PCR and CellSearchâ„¢ method will be the positivity sample rate | 1 day |
| Prognostic marker of relapse | Local recurrence, regional or metastatic head and neck cancer in the two years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| MASTRONICOLA Romina, MD | Institut de Cancérologie de Lorraine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut de Cancérologie de Lorraine | Vandœuvre-lès-Nancy | 54519 | France |
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| ID | Term |
|---|---|
| D006258 | Head and Neck Neoplasms |
| D009360 | Neoplastic Cells, Circulating |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D009362 | Neoplasm Metastasis |
| D009385 | Neoplastic Processes |
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|
| 2 years |
| D010335 |
| Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |