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The purpose is to determine intrinsic properties of various immunohistochemical markers (FVIIIra, CD15, CD30, tryptase, TNFα, IL-1β, TGFα et TGFβ1) for diagnosis of vital wound, alone and in association (evaluation of sensibility with surgery wounds and evaluation of specificity with post-mortem wounds).
Secondary purposes are to measure the minimum time to obtain a positive labeling in vital wounds, and to evaluate inter-observer reproducibility of vitality diagnosis with different markers. Expression of microRNA miR 9, miR 21 et miR 198 will be also studied.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vital wounds | from abdominoplasty of alive persons |
| |
| Post-mortem wounds | from autopsy of deceased persons |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Abdominoplasty with exeresis of cutaneous tissue | Other |
| ||
| Collection of cutaneous tissue |
| Measure | Description | Time Frame |
|---|---|---|
| Sensibility of markers for vitality diagnosis | baseline | |
| Specificity of markers for vitality diagnosis | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Minimum time to obtain a labeling (between incision and devascularization) | baseline | |
| Coefficient of inter-observer correlation of vitality diagnosis (for reproducibility analysis) | baseline | |
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Inclusion Criteria:
Alive persons:
- Abdominoplasty
Deceased persons:
- Medico-scientific autopsy for diagnosis
Exclusion Criteria:
Alive persons:
Deceased persons:
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Patients operated in Plastic and Reconstructive Surgery and Maxillofacial Surgery departments at CHRU Nancy for therapeutic abdominoplasty.
Deceased patients, whose medico-scientific autopsies are performed for diagnosis in Anatomy and Pathological Cytology or Legal Medicine departments.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Laurent MARTRILLE | Contact | l.martrille@chru-nancy.fr |
| Name | Affiliation | Role |
|---|---|---|
| Laurent MARTRILLE | Service de Médecine Légale - CHRU de Nancy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU Nancy | Recruiting | Nancy | France |
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| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D061645 | Abdominoplasty |
| ID | Term |
|---|---|
| D003357 | Cosmetic Techniques |
| D013812 | Therapeutics |
| D019651 | Plastic Surgery Procedures |
| D013514 | Surgical Procedures, Operative |
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Cutaneous tissue
| Other |
|
| Expression level of miR 9 by qRT-PCR |
| baseline |
| Expression level of miR 21 by qRT-PCR | baseline |
| Expression level of miR 198 by qRT-PCR | baseline |