Depletion of Funds and Illness of principal investigator

Patients will have a Functional MRI before and after 10 hyperbaric Oxygen treatments.

Functional MRI studies will be done before and 4-6 weeks after Hyperbaric Oxygen treatment to assess changes in connectivity of resting state neural networks. 10 hyperbaric treatments at 2 atmospheres absolute for 1 hour at pressure will be administered. A review of symptoms and and thorough clinical neurological examination by an experienced neurologist familiar with these studies will be done before and 4-6 weeks after the hyperbaric treatments.

Inclusion Criteria:

• White Matter Hyperintensities on MRI
• 2 or more neurological symptoms or impairments e.g. gait disturbances, disequilibrium, cognitive decline, dysmetria, hyper-rflexia

Exclusion Criteria:

• Contraindication to hyperbaric oxygen treatment e.g. pulmonary emphysema, seizure disorder
• major eustachian tube dysfunction
• stroke with previous 6 months
• extreme cognitive impairment
• major depression
• history of migraine, electroshock therapy, brain irradiation, brain tumor, head trauma
• other uncontrolled co-morbidities, e.g. diabetes, renal or hepatic dysfunction, hypertension, thyroid disorders, carotid artery stenosis (>70%)