Efficacy and Safety of Ethanol Lock Therapy for the Prevention of Central Line-associated Bloodstream Infections

Efficacy and Safety of Ethanol Lock Therapy for the Prevention of Central Line-associated Bloodstream Infections

Patients on long-term parenteral nutrition (PN) are at high risk for central line-associated bloodstream infections (CLABSI). This study evaluates the efficacy and safety of ethanol lock therapy for CLABSI prophylaxis in adult patients on PN.

Inclusion Criteria:

• Adult patients (ages 18-80) on PN with silicone-based central venous catheters

Exclusion Criteria:

• Weight ≤ 50 kg
• Allergy/hypersensitivity/intolerance to ethanol or heparin
• Pregnancy or breastfeeding
• Patient taking metronidazole, disulfiram, or isoniazid
• History of alcohol abuse
• History of heparin-induced thrombocytopenia (HIT) or have an active hypocoagulable state