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The inclusions have been suspended from 03/18/2020 during the confinement period.
In the meantime, a publication has appeared showing that the chest ultrasound has entered the common practice in the management of bronchiolitis.
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The diagnosis of bronchiolitis, the most frequent lung infectious disease in infancy, is based on clinical examination. Chest X-ray is proposed when a lung parenchymal condensation is suspected. Chest ultrasound is supposed to be a useful tool in the diagnosis of these complication but is poorly evaluated. We aim to compare chest X-ray and chest ultrasound for the diagnosis of parenchymal condensation in infant with bronchiolitis.
900 to 1000 children are admitted each year for bronchiolitis in the pediatric emergency department of the Toulouse Children Hospital. The diagnosis is based on clinical examination, but in some cases furthers examinations such as chest X-ray are necessary in order to look for a parenchymal condensation. Even if French recommendations do not place chest ultrasound in the care pathway to date, many recent studies show the usefulness, rapidity and reliability of ultrasound in parenchymal abnormalities. But regarding the bronchiolitis, few studies are available and including limited numbers of patients. In addition, the reduction of irradiation is a main goal, especially in children.
We propose to performed a chest ultrasound in infants (<24 months) admitted for bronchiolitis with an available chest X-ray, in order to compare the performance of both examinations (X-ray and ultrasound) for the diagnosis of parenchymal condensation. Besides, to correlate initial chest ultrasound results and clinical evolution, parents will be contacted by phone 1 month after inclusion.
Primary outcome: The primary outcome is the sensitivity and specificity values of chest ultrasound for the diagnosis of parenchymal condensations diagnosed by chest X-ray. Positive and negative predictive values will also be estimated. This outcome is evaluated at the first visit (T0).
Secondary outcomes:
Follow-up parameters are recorded during a telephone call 1 month after inclusion.
Study design : It is a longitudinal, monocentric and prospective study with the aim to evaluate a diagnostic examination.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bronchiolitis children | Other | Under two years old patient with bronchiolitis will have thoracic radiology |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| radiology | Radiation | The investigators propose to performed a chest ultrasound in infants (<24 months) admitted for bronchiolitis with an available chest X-ray |
|
| Measure | Description | Time Frame |
|---|---|---|
| Presence of parenchymatous opacity | Presence of parenchymatous opacity during thoracic radiological exam | Inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Radiological anomaly | Description of all pleuropulmonary anomaly in every radiological anomaly | Inclusion |
| Parenchymatous retractable (or non retractable) opacity | Assessment of radiographic capacity to differentiate Parenchymatous retractable (or non retractable) opacity |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marine MICHELET, MD | University Hospital, Toulouse | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital des Enfants, Unité de pneumo-allergologie pédiatrique | Toulouse | 31059 | France |
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| ID | Term |
|---|---|
| D001988 | Bronchiolitis |
| ID | Term |
|---|---|
| D001991 | Bronchitis |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D001982 | Bronchial Diseases |
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| ID | Term |
|---|---|
| D014965 | X-Rays |
| ID | Term |
|---|---|
| D060733 | Electromagnetic Radiation |
| D055590 | Electromagnetic Phenomena |
| D060328 | Magnetic Phenomena |
| D055585 | Physical Phenomena |
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| Inclusion |
| D012140 |
| Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D011827 | Radiation |
| D011839 | Radiation, Ionizing |