Low Carbohydrate Diet vs. High Carbohydrate Diet in Type 1 Diabetes

Low Carbohydrate Diet vs. High Carbohydrate Diet in Type 1 Diabetes: A Randomized Crossover Study

The aim of the study is to investigate glycemic control during a low carbohydrate diet compared with during a high carbohydrate diet in adults with insulin pump treated type 1 diabetes.

Inclusion Criteria:

• Type 1 diabetes ≥3 years
• Insulin pump use ≥1 year
• HbA1c ≥53 mmol/mol (7.0%)
• BMI 20-27 kg/m2
• Willingness to count carbohydrates and use the insulin pump bolus calculator for all boluses during the intervention periods
• Willingness to use continuous glucose monitoring consistently during the intervention periods

Exclusion Criteria:

• Females of childbearing potential who are pregnant, breast-feeding or intend to become pregnant or are not using adequate contraceptive methods
• Use of SGLT-2-inhibitors
• Use of corticosteroids during or within 30 days prior to the intervention periods
• Celiac disease
• Inflammatory bowel disease
• Macroalbuminuria
• Active proliferative retinopathy combined with an HbA1c ≥ 75 mmol/mol (9.0%)
• Known or suspected alcohol or drug abuse
• Other concomitant medical or psychological condition that according to the investigator's assessment makes the patient unsuitable for study participation